Ovarian fibrosarcoma producing multiple cytokines
Ovarian fibrosarcoma producing multiple cytokines
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DOI：
10.1046/j.1440-1827.2001.01270.x
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发表时间：
2001-09-01
影响因子：
2.2
通讯作者：
Suzuki, T
中科院分区：
文献类型：
--
作者：
Fukuda, T;Yamaguchi, T;Suzuki, T
介绍了一例产生多种细胞因子的卵巢纤维肉瘤。肿瘤发生在一名日本女性的左侧卵巢，伴有上腹痛、弛张热、白细胞增多和轻微血小板增多，骨髓中肥大细胞中度增多，但没有激素异常。切除的卵巢肿瘤包膜良好，由梭形肿瘤细胞和散在的小管组成，有明显的肥大细胞浸润。 14个月后，肿瘤在盆腔内复发，并伴有与原发肿瘤相似的体征和症状。白细胞介素 (IL)-6 和肿瘤坏死因子 (TNF)-α 的血清水平升高。复发性肿瘤显示出与原发性肿瘤相似的组织学发现，除了缺乏肾小管之外。肿瘤细胞显示波形蛋白、IL-6、TNF-α和α-抑制素呈局灶性阳性免疫反应。使用从复发肿瘤获得的总RNA进行的逆转录聚合酶链反应证明了IL-6、IL-10、TNF-α和干细胞因子的mRNA表达。这是一个罕见的案例！卵巢纤维肉瘤产生多种细胞因子，导致临床表现不典型。
A case of ovarian fibrosarcoma producing multiple cytokines is presented. The tumor occurred in the left ovary of a Japanese woman with epigastralgia, remittent fever, leukocytosis and slight thrombocytosis with moderate increase of mast cells in bone marrow, but lack of hormonal abnormality. The resected tumor of the ovary was well encapsulated and it was composed of spindle-shaped tumor cells and scattered tubules with marked mast cell infiltration. The tumor recurred in the pelvic cavity 14 months later, accompanied by similar signs and symptoms as occurred: with the primary tumor. Serum levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha were elevated. The recurrent: tumor showed similar histological findings to those of the primary tumor, except for lack of tubules. Tumor cells revealed a focally positive immunoreaction for vimentin, IL-6 and TNF-alpha and alpha-inhibin. Reverse transcription-polymerase chain reaction using total RNA obtained from the recurrent tumor demonstrated mRNA expression of IL-6, IL-10, TNF-alpha and stem cell factor. This is a rare case of! ovarian fibrosarcoma producing multiple cytokines, resulting in atypical clinical findings.