Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade
Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade
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DOI：
10.1126/science.280.5372.2121
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发表时间：
1998-06-26
期刊：
影响因子：
56.9
通讯作者：
Muller, RV
中科院分区：
文献类型：
--
作者：
Kentros, C;Hargreaves, E;Muller, RV
海马锥体细胞被称为位置细胞，因为每个细胞只有当动物处于环境的特定部分时才倾向于发射-细胞的发射场。使用N-甲基-D-天冬氨酸（NMDA）谷氨酸受体的急性药理学阻断来研究基于NMDA的突触可塑性如何参与放电场的形成和维持。结果表明，在一个新的环境中，放电场的形成和短期稳定性涉及的可塑性，是独立的NMDA受体激活。相比之下，新建立的放电场的长期稳定需要正常的NMDA受体功能，因此，可能与其他NMDA依赖的过程，如长时程增强和空间团队。
Hippocampal pyramidal cells are called place cells because Each cell tends to fire only when the animal is in a particular part of the environment-the cell's firing field. Acute pharmacological blockade, of N-methyl-D-aspartate (NMDA) glutamate receptors was used to investigate how NMDA-based synaptic plasticity participates in the formation and maintenance of the firing fields. The results suggest that the formation and short-term stability of firing fields in a new environment involve plasticity that is independent of NMDA receptor activation. By contrast, the long-term stabilization of newly established firing fields required normal NMDA receptor function and, therefore, may be related to other NMDA-dependent processes such as long-term potentiation and spatial teaming.