A facile synthesis of a polyhydroxylated 2-azabicyclo[3.2.1]octane.
A facile synthesis of a polyhydroxylated 2-azabicyclo[3.2.1]octane.
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DOI：
10.1021/jo0619231
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发表时间：
2007-01
期刊：
影响因子：
--
通讯作者：
Damon D. Reed;S. Bergmeier
中科院分区：
文献类型：
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作者：
Damon D. Reed;S. Bergmeier
合成或天然氮杂糖作为糖加工酶的过渡态模拟物，已显示出作为一种治疗各种疾病状态的方法的前景。虽然官能化双环[3.2.1]辛烷的合成已有报道，但合成过程相对较长且产率较低。本文报道了可选择性官能化的多羟基2-氮杂双环[3.2.1]辛烷的简便合成方法。
Synthetic or natural aza-sugars have shown promise as a therapeutic approach to a variety of disease states by acting as transition state mimics to sugar processing enzymes. Although the synthesis of functionalized bicyclo[3.2.1]octanes has been reported, the procedures are relatively long and low yielding. Herein, we report the facile synthesis of polyhydroxylated 2-azabicyclo[3.2.1]octane that can be selectively functionalized.