DNA-Chitosan Aerogels and Regenerated Hydrogels with Extraordinary Mechanical Properties
DNA-Chitosan Aerogels and Regenerated Hydrogels with Extraordinary Mechanical Properties
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DOI：
10.1021/acsapm.1c01585
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发表时间：
2021-12-18
影响因子：
5
通讯作者：
Shchipunov, Yury
中科院分区：
文献类型：
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作者：
Postnova, Irina;Sarin, Sergey;Shchipunov, Yury
最近的研究表明，天然ds-DNA和壳聚糖可以在没有共同相分离和沉淀的情况下共同聚集，形成半透明的均匀水凝胶。这种简单的方法包括通过在DNA存在下的溶液逐渐酸化使多糖逐渐充电，这慢慢地加强了它们之间的静电相互作用，排除了快速和不受控制的合作结合，这是一个众所周知的与凝聚有关的问题。制备的均相水凝胶具有很强的物理性质。从原始水凝胶制备的气凝胶以及通过气凝胶的再水化恢复的水凝胶中观察到非凡的机械强度和弹性。气凝胶匹配高度交联的合成聚氨酯泡沫，尽管DNA与壳聚糖仅通过静电相互作用结合，而不使用有毒的交联剂。由于其生物相容性、可生物降解性和可再生资源，水凝胶和气凝胶可能取代典型的合成聚合物。通过包裹量子点、二氧化钛纳米粒子和染料来制造具有发光、传感和光催化功能的生物纳米复合材料，展示了一些可能的应用。
It has recently been shown that native ds-DNA and chitosan can coassemble without common phase separation and precipitation, forming a translucent homogeneous hydrogel. This simple approach consists of progressive charging of the polysaccharide through gradual acidification of a solution in the presence of DNA, which slowly strengthens the electrostatic interactions between them, ruling out fast and uncontrolled cooperative association, which is a well-known problem associated with coacervation. Homogeneous hydrogels thus fabricated demonstrated mechanical properties characteristic of quite strong physical hydrogels. Extraordinary mechanical strength and elasticity have been observed in aerogels prepared from an original hydrogel and also in hydrogels, which were restored by the rehydration of aerogels. Aerogels match highly cross-linked synthetic polyurethane foams despite DNA with chitosan being bound only via electrostatic interactions without using a toxic cross-linking agent. Owing to their biocompatibility, biodegradability, and available renewable resources, hydrogels and aerogels might replace typical synthetic polymers. The fabrication of bionanocomposites with luminescent, sensing, and photocatalytic functionalities by entrapping quantum dots, titania nanoparticles, and dyes demonstrates some possible applications.