TCP10L negatively regulates alpha-fetoprotein expression in hepatocellular carcinoma
TCP10L negatively regulates alpha-fetoprotein expression in hepatocellular carcinoma
复制标题
TCP10L 负向调节肝细胞癌中甲胎蛋白的表达
DOI：
10.5483/bmbrep.2020.53.8.008
复制
发表时间：
2020-08-31
期刊：
影响因子：
3.8
通讯作者：
Wu, Jiaxue
中科院分区：
文献类型：
--
作者：
Shen, Suqin;Feng, Huan;Wu, Jiaxue
甲胎蛋白（AFP）是肝细胞癌（HCC）最常用和最可靠的生物标志物之一。然而，AFP在HCC中表达的潜在机制知之甚少。在这项研究中，我们发现TCP10L，一个在肝脏中特异性表达的基因，在HCC中下调，并且其表达与AFP表达呈负相关。此外，过表达TCP10L抑制AFP表达，而敲低TCP10L则增加AFP表达，表明TCP10L可能是AFP的负调节因子。我们发现TCP10L与AFP启动子相关，并抑制AFP启动子驱动的转录活性。综上所述，这些结果表明，TCP10L负调控肝癌AFP表达，它可能是一个潜在的预后标志物和肝癌的治疗靶点。
Alpha-fetoprotein (AFP) is one of the most commonly used and reliable biomarkers for Hepatocellular carcinoma (HCC). However, the underlying mechanism of AFP expression in HCC is poorly understood. In this study, we found that TCP10L, a gene specifically expressed in the liver, is down-regulated in HCC and that its expression inversely correlates with AFP expression. Moreover, overexpression of TCP10L suppresses AFP expression whereas knockdown of TCP10L increases AFP expression, suggesting that TCP10L might be a negative regulator of AFP. We found that TCP10L is associated with the AFP promoter and inhibits AFP promoter-driven transcriptional activity. Taken together, these results indicate that TCP10L negatively regulates AFP expression in HCC and that it could be a potential prognostic marker and therapeutic target for HCC.