Correlated multisecond oscillations in firing rate in the basal ganglia: modulation by dopamine and the subthalamic nucleus.
Correlated multisecond oscillations in firing rate in the basal ganglia: modulation by dopamine and the subthalamic nucleus.
复制标题
基底神经节放电率的相关多秒振荡：多巴胺和底丘脑核的调节。
DOI：
10.1016/s0306-4522(02)00921-1
复制
发表时间：
2003
期刊：
影响因子：
3.3
通讯作者：
Walters,JR
中科院分区：
文献类型：
--
作者：
Ruskin,DN;Bergstrom,DA;Tierney,PL;Walters,JR
本实验室以前的研究表明，清醒大鼠基底神经节中的许多神经元具有多秒(<；0.5赫兹)的放电频率周期。通过系统注射多巴胺(DA)激动剂，这些振荡的频率和规律性显著增加。由于振荡活动如果被许多神经元共享，应该会对功能产生更大的影响，因此通过记录同一半球苍白球和黑质网状部的一对神经元，或清醒、束缚的大鼠对侧苍白球神经元对，评估了多秒振荡的相关性水平。用互相关(90-180 S滞后)和谱分析来表征相关振荡。在基线(n=50)记录的配对中，38%的配对显示出相关的多秒振荡。位相关系接近0°或180°。注射DA激动剂使大脑半球内和大脑半球间的相关发生率显著增加至94%(n=17)。注射DA激动剂后，苍白球/黑质神经元对的时相关系仅集中在180°附近，苍白球神经元的半球间对的时相关系集中在0°附近。损毁丘脑底核(n=8)后，尽管苍白球和黑质网状部之间的一致时相关系被破坏，但相关的多秒振荡(或多秒振荡本身)的发生率没有改变。损毁丘脑底核也可阻断阿朴吗啡引起的振荡周期缩短和振荡幅度增加，并显著减弱阿朴吗啡引起的平均放电频率的改变。这些数据表明，基底节的多秒振荡可以在核之间关联，而DA受体的激活增加了这种关联的水平，并在这些多秒时间尺度上组织了核间时相关系。虽然丘脑底核不是产生或传递这些慢振荡所必需的，但它参与了DA激动剂诱导的平均放电频率、振荡周期和核间时相关系的调制。这些数据进一步支持DA在调节基底节的相干振荡活动中的作用，以及丘脑底核在形成刺激DA受体对基底节输出的影响中的作用。
Previous studies from this laboratory have shown that many neurons in the basal ganglia have multisecond (<0.5 Hz) periodicities in firing rate in awake rats. The frequency and regularity of these oscillations are significantly increased by systemically injected dopamine (DA) agonists. Because oscillatory activity should have greater functional impact if shared by many neurons, the level of correlation of multisecond oscillations was assessed by recording pairs of neurons in the globus pallidus and substantia nigra pars reticulata in the same hemisphere, or pairs of globus pallidus neurons in opposite hemispheres in awake, immobilized rats. Cross-correlation (90–180 s lags) and spectral analysis were used to characterize correlated oscillations. Thirty-eight percent of pairs recorded in baseline (n=50) demonstrated correlated multisecond oscillations. Phase relationships were near 0 or 180°. DA agonist injection significantly increased the incidence of correlation (intra- and interhemispheric) to 94% (n=17). After DA agonist injection, phase relationships of globus pallidus/substantia nigra neuron pairs were exclusively concentrated near 180°, and phases of interhemispheric pairs of globus pallidus neurons were concentrated near 0°. After subthalamic nucleus lesion (n=8), the incidence of correlated multisecond oscillations (or of multisecond oscillations per se) was not changed, although the consistent phase relationship between the globus pallidus and substantia nigra pars reticulata was disrupted. Subthalamic lesion also blocked apomorphine-induced decreases in oscillatory period and increases in oscillation amplitude, and significantly attenuated apomorphine-induced changes in mean firing rate. The data demonstrate that multisecond oscillations in the basal ganglia can be correlated between nuclei, and that DA receptor activation increases the level of correlation and organizes internuclear phase relationships at these multisecond time scales. While the subthalamic nucleus is not necessary for generating or transmitting these slow oscillations, it is involved in DA agonist-induced modulation of mean firing rate, oscillatory period, and internuclear phase relationship. These data further support a role for DA in modulating coherent oscillatory activity in the basal ganglia, and for the subthalamic nucleus in shaping the effects of DA receptor stimulation on basal ganglia output.