Development of Hypothalamic Neural Networks Controlling Appetite
Development of Hypothalamic Neural Networks Controlling Appetite
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DOI：
10.1159/000264396
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发表时间：
2010-01-01
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影响因子：
--
通讯作者：
Bouret, Sebastien G.
中科院分区：
文献类型：
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作者：
Bouret, Sebastien G.
下丘脑在成人生活中控制食欲方面发挥着重要作用。它从妊娠早期开始并持续到产后期间经历巨大的生长。在这个发育时期，多种过程塑造了参与控制饮食的下丘脑核团。这些包括填充这些区域的新细胞的诞生（神经发生）、这些细胞迁移到最终目的地、选择性神经元死亡，以及最后功能性神经连接的发展。这些发育过程中的每一个都代表了一个重要的脆弱时期，在此期间，产前（宫内）和产后早期环境的改变可能对下丘脑的发育和功能产生长期且潜在不可逆转的后果。代谢激素，包括脂肪细胞衍生的激素瘦素，最近已成为指导下丘脑编程的环境营养感应装置的可能介质。版权所有 (C) 2010 S. Karger AG，巴塞尔
The hypothalamus plays an essential role in controlling appetite during adult life. It undergoes tremendous growth beginning early in gestation and continuing during the postnatal period. During this developmental period, a variety of processes shape the hypothalamic nuclei involved in the control of eating. These include the birth of new cells that populate these areas (neurogenesis), the migration of these cells to their final destinations, selective neuronal death, and, finally, the development of functional neural connections. Each of these developmental processes represents an important period of vulnerability during which alterations of the pre- (intrauterine) and early postnatal environments may have long-term and potentially irreversible consequences on hypothalamic development and function. Metabolic hormones, including the adipocyte-derived hormone leptin, have recently emerged as likely mediators of the environmental nutrient-sensing apparatus that directs hypothalamic programming. Copyright (C) 2010 S. Karger AG, Basel