Clinicopathological prognostic factors of oral tongue squamous cell carcinoma: a retrospective study of 202 cases
Clinicopathological prognostic factors of oral tongue squamous cell carcinoma: a retrospective study of 202 cases
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DOI：
10.1016/j.ijom.2014.01.014
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发表时间：
2014-07-01
影响因子：
2.4
通讯作者：
Coletta, R. D.
中科院分区：
文献类型：
--
作者：
Rodrigues, P. C.;Miguel, M. C. C.;Coletta, R. D.
尽管一些组织病理学参数和分级系统已被描述为可预测口腔鳞状细胞癌（OSCC）的治疗反应和结果，但没有一个被普遍接受。最近，一种新的评分系统，即组织学风险模型，被认为是 OSCC 复发和总生存期的强大预测工具。本研究的目的是验证组织学风险模型在 202 名口腔/移动舌鳞状细胞癌 (OTSCC) 各个阶段患者的队列中的预测作用。从病历中收集人口统计和临床数据，并使用组织学风险模型评估肿瘤。使用chi(2)检验、Kaplan-Meier方法和Cox回归模型进行统计分析。组织学风险模型显示与人口统计学或临床参数没有统计相关性，并且不能预测 OTSCC 患者的结果。然而，多变量回归分析显示临床疾病阶段与疾病结果存在显着相关性。尽管在确定预测参数和组织学系统方面做出了巨大努力，但临床特征仍然是 OTSCC 患者最可靠的预后因素。
Although several histopathological parameters and grading systems have been described as predictive of the treatment response and outcome of oral squamous cell carcinoma (OSCC), none is universally accepted. A new scoring system, the histological risk model, was recently described to be a powerful predictive tool for recurrence and overall survival in OSCC. The aim of this study was to verify the predictive role of the histological risk model in a cohort of 202 patients at all stages of oral/mobile tongue squamous cell carcinoma (OTSCC). Demographic and clinical data were collected from the medical records and the tumours were evaluated using the histological risk model. Statistical analyses were performed using the chi(2) test, the Kaplan-Meier method, and the Cox regression model. The histological risk model showed no statistical correlation with demographic or clinical parameters and did not Predict the outcome of the OTSCC patients. However, multivariate regression analysis revealed a significant correlation of the clinical disease stage with the disease outcome. Despite major efforts to identify hew predictive parameters and histological systems, clinical features are still the most reliable prognostic factors for patients with OTSCC.