BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex
BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex
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DOI：
10.1038/nn1699
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发表时间：
2006-06-01
影响因子：
25
通讯作者：
Cramer, Steven C.
中科院分区：
文献类型：
--
作者：
Kleim, Jeffrey A.;Chan, Sheila;Cramer, Steven C.
运动训练可以诱导初级运动皮层产生深刻的生理可塑性，包括皮质脊髓输出和运动地图地形图的变化。使用经颅磁刺激，我们表明，运动诱发电位和运动地图重组的幅度的训练依赖性增加减少在健康受试者与val66met多态性的脑源性神经营养因子基因（BDNF），相比受试者没有多态性。结果表明，BDNF参与介导人类运动皮层的经验依赖性可塑性。
Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a val66met polymorphism in the brain-derived neurotrophic factor gene ( BDNF), as compared to subjects without the polymorphism. The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex.