Palladium-Catalyzed ortho-Selective C-H Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles
Palladium-Catalyzed ortho-Selective C-H Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles
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DOI：
10.1002/anie.201305388
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发表时间：
2014-01-13
影响因子：
16.6
通讯作者：
Yu, Jin-Quan
中科院分区：
文献类型：
--
作者：
Ma, Sandy;Villa, Giorgio;Yu, Jin-Quan
我们公开了一种钯催化芳烃邻位选择性C-H氘代反应的方案。苯乙酸和苯甲酸是该反应的合适底物。该反应提供了邻氘代苯乙酸和苯甲酸的催化途径，并证明了通过弱配位和强配位结合在一起的钯代化合物中间体的反应性的显著差异。
We disclose a protocol for the palladium-catalyzed ortho-selective C-H deuteration of arenes. Phenylacetic acids and benzoic acids are suitable substrates for this reaction. This reaction offers a catalytic route to ortho-deuterated phenylacetic acids and benzoic acids and demonstrates the sharp difference in reactivity of palladacycle intermediates held together by weak and strong coordination.