Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular
Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular
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DOI：
10.3390/md9060944
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发表时间：
2011-06-01
期刊：
影响因子：
5.4
通讯作者：
Wen, Zhi-Hong
中科院分区：
文献类型：
--
作者：
Su, Jui-Hsin;Wen, Zhi-Hong
对台湾软珊瑚Sinularia triangular进行化学分析，分离出五种西松烷二萜化合物1-5，包括两种新的代谢产物，triangulenes A（1）和B（2）。新代谢物的结构是基于广泛的光谱分析，特别是质谱和2D NMR（H-1-H-1 COSY、HMQC、HMBC和NOESY）光谱确定的。Metastasis 3和5对人肿瘤细胞系CCRF-CEM和DLD-1表现出中等细胞毒性。此外，3-5通过抑制iNOS蛋白的表达，在脂多糖刺激的RAW 264.7巨噬细胞中显示出显著的体外抗炎活性。Metastrophic 4和Metastrophic 5也有效地降低巨噬细胞中考克斯-2蛋白的表达。
Chemical examination of the Taiwanese soft coral Sinularia triangular led to the isolation of five cembrane-based diterpenoids 1-5, including two new metabolites, triangulenes A (1) and B (2). The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and 2D NMR (H-1-H-1 COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 3 and 5 exhibited moderate cytotoxicity to human tumor cell lines CCRF-CEM and DLD-1. Furthermore, 3-5 displayed significant in vitro anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Metabolites 4 and 5 also effectively reduced the expression of the COX-2 protein in the macrophages.