Antibiotics in the Treatment of Periodontitis: A Systematic Review of the Literature.
Antibiotics in the Treatment of Periodontitis: A Systematic Review of the Literature.
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DOI：
10.1155/2021/6846074
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发表时间：
2021
影响因子：
2.1
通讯作者：
Nasri W
中科院分区：
文献类型：
--
作者：
Hammami C;Nasri W
全身性抗生素是非手术牙周治疗（NSPT）的替代辅助疗法之一。不同的治疗方案已被提出，但其适应症和有效性仍存在争议。本研究的目的是评估非手术清创后初始治疗期间添加抗生素的有效性，并比较不同的抗菌药物处方方案。使用适当的MeSH词通过MEDLINE和EBSCOhost数据库进行电子检索。目标研究必须在最近五年内发表。从选定的研究中提取数据并进行分析。研究选择是根据纳入和排除标准进行的。我们的综述纳入了7项随机临床试验。他们的数据是通过为此目的建立的网格提取出来的。总的来说，已经提出了不同的方案，与安慰剂组相比，几乎所有方案都产生了更好的临床和微生物结果。本综述的总体结果显示，无论我们纳入的研究中使用何种抗菌药物，使用抗生素作为NSPT的辅助治疗都具有积极作用。在NSPT中，PD bb0 - 6 mm的部位可能从辅助使用抗生素中获益最多。该试验在Clinicaltrials.gov注册编号：NCT02829983 (Bechara Andere et al., 2016)；NCT02839421 (Ardila等，2020)；NCT02735395 (Borges et al., 2017)；NCT02359721 (Suryaprasanna et al., 2018)；和NCT01318928 （Hans, 2015）。
Systemic antibiotics present one of the alternative adjunctive therapies in nonsurgical periodontal treatment (NSPT). Different protocols have been proposed, but their indication and effectiveness are still controversial. The aim of this study is to assess the effectiveness of the addition of antibiotics after nonsurgical debridement during initial therapy and compare different antimicrobial prescription protocols. An electronic search was performed through MEDLINE and EBSCOhost databases using the appropriate MeSH words. The target studies have to be published during the last five years. Data from the selected studies were extracted and analyzed. Study selection was done based on inclusion and exclusion criteria. Seven randomized clinical trials were included in our review. Their data were extracted using a grid established for this purpose. Collectively, different protocols have been proposed and almost all of them yield superior clinical and microbiological results compared to the placebo group. The overall findings of this review show a positive effect of the use of antibiotics as an adjunctive to NSPT, regardless of the antimicrobial agents used in our included studies. Sites with PD > 6 mm may benefit most from the adjunctive use of antibiotics in NSPT. This trial is registered with Clinicaltrials.gov identifiers: NCT02829983 (Bechara Andere et al., 2016); NCT02839421 (Ardila et al., 2020); NCT02735395 (Borges et al., 2017); NCT02359721 (Suryaprasanna et al., 2018); and NCT01318928 (Hans, 2015).