FoxM1 and Wnt/β-catenin signaling in glioma stem cells.
FoxM1 and Wnt/β-catenin signaling in glioma stem cells.
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DOI：
10.1158/0008-5472.can-12-0953
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发表时间：
2012-11-15
期刊：
影响因子：
11.2
通讯作者：
Huang S
中科院分区：
文献类型：
--
作者：
Gong A;Huang S
癌症干细胞可能负责肿瘤的起始和维持。控制癌症干细胞的分子机制与各种信号通路的改变有关，包括Wnt/β-连环蛋白信号通路。经典的Wnt/β-连环蛋白信号传导途径是干细胞和祖细胞中的主要信号传导系统之一，并且Wnt/β-连环蛋白信号传导途径的异常激活在人类癌症中是常见的。与β-连环蛋白一样，FoxM 1已被发现在许多癌症中发挥重要作用。在这篇综述中，我们讨论了FoxM 1影响多种基因的表达和功能的证据，这些基因对癌症干细胞的生存、增殖、侵袭、血管生成和自我更新至关重要。我们强调了Wnt/β-catenin和FoxM 1信号通路在神经干细胞和祖细胞以及胶质瘤干细胞中的关键作用。我们还讨论了β-catenin和FoxM 1信号通路在调节胶质瘤干细胞的干细胞性和致瘤性中的串扰的证据。
Cancer stem cells may be responsible for tumor initiation and maintenance. The molecular mechanisms that control cancer stem cells are related to alterations in various signaling pathways, including the Wnt/β-catenin signaling pathway. The canonical Wnt/β-catenin signaling pathway is one of the major signaling systems in stem and progenitor cells, and aberrant activation of the Wnt/β-catenin signaling pathway is common in human cancers. As with β-catenin, FoxM1 has been found to play important roles in a number of cancers. In this review, we discussed the evidence for FoxM1 affects the expression and function of a variety of genes that are critical to the survival, proliferation, invasion, angiogenesis, and self-renewal of cancer stem cells. We highlight the pivotal roles of the Wnt/β-catenin and FoxM1 signaling pathways in neural stem and progenitor cells and glioma stem cells. We also discuss the evidence for crosstalk between the β-catenin and FoxM1 signaling pathways in the regulation of the stemness and tumorigenicity of glioma stem cells.