Sleep duration and mortality in Japan: the Jichi Medical School Cohort Study.
Sleep duration and mortality in Japan: the Jichi Medical School Cohort Study.
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DOI：
10.2188/jea.14.124
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发表时间：
2004-07
影响因子：
4.7
通讯作者：
Kajii E
中科院分区：
文献类型：
--
作者：
Amagai Y;Ishikawa S;Gotoh T;Doi Y;Kayaba K;Nakamura Y;Kajii E
背景：虽然睡眠是最重要的健康相关因素之一，但睡眠时间与死亡率之间的关系尚未得到充分的讨论。方法：研究对象为JICH医学院队列研究的11,325名参与者(4,419名男性和6,906名女性)，这是一项基于人群的前瞻性研究。基线数据是从1992年4月至1995年7月在日本12个农村地区通过问卷调查和健康检查获得的。主要观察指标为截至2001年12月31日的死亡证明中的全因死亡率和特定死因死亡率。采用Cox比例风险模型分析睡眠时间与死亡率的关系。结果：在平均8.2年的随访期内，共观察到495例死亡(男性289例，女性206例)。在调整了年龄、收缩压、血清总胆固醇、体重指数、吸烟习惯、饮酒习惯、教育程度和婚姻状况后，睡眠少于6小时和9小时或更长的个体的全因死亡风险比(95%可信区间)分别为男性2.4(1.3-4.2)和1.1(0.8-1.6)，女性0.7(0.2-2.3)和1.5(1.0-2.4)，与睡眠7-7.9小时的个体相比。结论：我们的数据表明，睡眠时间短的男性和睡眠时间长的女性死亡风险较高。
BACKGROUND: Although sleep is one of the most important health-related factors, relationship between sleep duration and mortality has not been fully discussed. METHODS: Study subjects were 11,325 participants (4,419 males and 6,906 females) in the Jich Medical School Cohort Study, a population-based prospective study. Baseline data were obtained by questionnaire and health checkups between April 1992 and July 1995 in 12 rural areas in Japan. Main outcome measures were all-cause and cause-specific mortality derived from death certificates up to December 31, 2001. Cox’s proportional hazard models were applied to analyze the association of sleep duration with mortality. RESULTS: A total of 495 deaths (289 males and 206 females) were observed during the average of 8.2-year follow-up period. After adjusting for age, systolic blood pressure, serum total cholesterol, body mass index, smoking habits, alcohol drinking habits, education, and marital status, the hazard ratios (95% confidence intervals) of all-cause mortality for individuals sleeping shorter than 6 hours and 9 hours or longer were 2.4 (1.3-4.2) and 1.1 (0.8-1.6) in males, and 0.7 (0.2-2.3) and 1.5 (1.0-2.4) in females, respectively, relative to those with 7-7.9 hours sleep. CONCLUSION: Our data suggest that males with short sleep and females with long sleep were at an elevated risk of death.