Gray matter volume reductions in patients with schizophrenia: A replication study across two cultural backgrounds
Gray matter volume reductions in patients with schizophrenia: A replication study across two cultural backgrounds
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DOI：
10.1016/j.pscychresns.2019.08.008
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发表时间：
2019-10-30
影响因子：
2.3
通讯作者：
Miyata, Jun
中科院分区：
文献类型：
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作者：
Koelkebeck, Katja;Dannlowski, Udo;Miyata, Jun
精神分裂症患者的结构性灰质（GM）体积减少很少在两个不同部位重复，培养和临床特征的影响仍未解决。因此，我们使用 3 T 磁共振成像评估了精神分裂症患者的 GM 体积减少，以在两个独立且文化不同的背景（德国、日本）中复制结果，并研究脑体积减少对临床特征的影响。总共有 163 名德国人（80 名患者）和 203 名日本人（83 名患者）参与者参与了分析。基于体素的形态测量 (VBM) 用于研究组之间和两个位点之间的结构差异，比较局部 GM 体积。临床变量用于分析与社会文化背景无关的影响。在这两个数据集中，发现患者和对照组之间额叶和颞叶皮质部分的 GM 普遍减少，表明诊断的影响很大，而部位的影响很小。临床特征的调查显示，主要在日本样本中，氯丙嗪等价物对 GM 体积减少的影响最强。尽管位点的影响很小，但两组之间的几个大脑区域并不重叠。因此，精神分裂症患者的两个部位的 GM 可能受到不同的影响。
Structural gray matter (GM) volume reductions in patients with schizophrenia have rarely been replicated across two different sites, the impact of culture and clinical characteristics remains unresolved. Hence, we assessed GM volume reductions in patients with schizophrenia using 3 T magnetic resonace imaging to replicate results across two independent and culturally different backgrounds (Germany, Japan), and to investigate the impact of brain volume reductions on clinical characteristics. In total, 163 German (80 patients) and 203 Japanese (83 patients) participants were included in the analysis. Voxel-based morphometry (VBM) was used to investigate structural differences between the groups and across the two sites, comparing local GM volumes. Clinical variables were used to analyze effects unrelated to the socio-cultural background. Across both data sets, widespread GM reductions in frontal and temporal cortical parts were found between patients and controls, indicating strong effects of diagnosis and only small effects of site. The investigation of clinical characteristics revealed the strongest effects for chlorpromazine equivalents on GM volume reductions primarily in the Japanese sample. Although the effects of site are small, several brain regions do not overlap between the two groups. Thus, GM may be affected differently at the two sites in patients with schizophrenia.