Concentration of oestrogens and androgens in human ovarian venous plasma and follicular fluid throughout the menstrual cycle.
Concentration of oestrogens and androgens in human ovarian venous plasma and follicular fluid throughout the menstrual cycle.
复制标题
整个月经周期中人卵巢静脉血浆和卵泡液中雌激素和雄激素的浓度。
作者：
K. McNatty;D. Baird;A. Bolton;P. Chambers;C. Corker;H. Mclean
本文测定了月经周期不同阶段妇女外周血、卵巢静脉血和卵泡液中雄烯二酮、睾酮、雌酮和雌二醇-17β的浓度。在月经周期的所有阶段，小卵泡(直径小于8 mm)和大卵泡(直径大于或等于8 mm)的雌二醇浓度相似，但在卵泡中晚期达到峰值(约1500 ng/ml)。在排卵前的大卵泡中，雄烯二酮的浓度在周期中期最低，此时卵巢静脉的分泌量明显增加。大卵泡(大于或等于8 mm)的睾酮浓度在卵泡期变化不大，而小卵泡的睾酮浓度在周期中期有一个峰值。周期中期外周血浆睾酮和雄烯二酮浓度升高可能是由于排卵前卵泡向卵巢静脉分泌增多所致。提示排卵前卵泡卵泡液中雄烯二酮浓度较低是由于雌激素合成过程中颗粒细胞芳构化增加所致。
The concentrations of androstenedione, testosterone, oestrone and oestradiol-17beta were measured in peripheral and ovarian venous blood and follicular fluid of women at various stages of the menstrual cycle. The concentration of oestradiol was similar in small follicles (diameter less than 8 mm) at all stages of the menstrual cycle and in large follicles (diameter greater than or equal to 8 mm) except during the mid- and late follicular phase when the concentration reached a peak (approximately 1500 ng/ml). The concentration of androstenedione was lowest in large preovulatory follicles at midcycle at a time when the secretion into the ovarian vein was markedly increased. The concentration of testosterone in large follicles (greater than or equal to 8 mm) was unchanged during the follicular phase whereas in small follicles there was a peak at mid-cycle. The rise in the concentration of testosterone and androstenedione at mid-cycle in peripheral plasma may be due to increased secretion by the preovulatory follicle into the ovarian vein. It is suggested that the relatively low concentration of androstenedione in follicular fluid of the preovulatory follicle arises from increased aromatization by granulosa cells in the course of oestrogen synthesis.