The fibrous character of pericellular matrix mediates cell mechanotransduction.
The fibrous character of pericellular matrix mediates cell mechanotransduction.
复制标题
DOI：
10.1016/j.jmps.2023.105423
复制
发表时间：
2023-08
影响因子：
5.3
通讯作者：
Xiangjun Peng;Yuxuan Huang;G. Genin
中科院分区：
文献类型：
--
作者：
Xiangjun Peng;Yuxuan Huang;G. Genin
实体组织中的细胞感知并响应机械信号，这些信号通过细胞外基质 (ECM) 传输，传输距离是其大小的许多倍。这种远距离力传递已知是由胶原纤维 ECM 网络中的应变硬化和屈曲引起的，但也必须穿过细胞通过分泌和压缩附近胶原蛋白形成的更致密的细胞周基质 (PCM)。然而，PCM 在机械信号传输中的作用仍不清楚。因此，我们研究了嵌入纤维胶原 ECM 和 PCM 中的细胞的理想化计算模型。我们的研究结果表明，与 PCM 相关的较小网络孔径会减弱张力驱动的胶原纤维排列，破坏长程力传递并保护细胞免受机械应力的影响。然而，细胞体的伸长或各向异性细胞收缩可以补偿这些效应，从而实现长距离力传输。结果与最近的实验一致，这些实验强调了 PCM 对保护细胞免受高应力的影响。结果对发育、伤口愈合和纤维化中机械信号的传递具有影响。
Cells in solid tissues sense and respond to mechanical signals that are transmitted through extracellular matrix (ECM) over distances that are many times their size. This long-range force transmission is known to arise from strain-stiffening and buckling in the collagen fiber ECM network, but must also pass through the denser pericellular matrix (PCM) that cells form by secreting and compacting nearby collagen. However, the role of the PCM in the transmission of mechanical signals is still unclear. We therefore studied an idealized computational model of cells embedded within fibrous collagen ECM and PCM. Our results suggest that the smaller network pore sizes associated with PCM attenuates tension-driven collagen-fiber alignment, undermining long-range force transmission and shielding cells from mechanical stress. However, elongation of the cell body or anisotropic cell contraction can compensate for these effects to enable long distance force transmission. Results are consistent with recent experiments that highlight an effect of PCM on shielding cells from high stresses. Results have implications for the transmission of mechanical signaling in development, wound healing, and fibrosis.