Melatonin excretion rhythms in the cultured pineal organ of the lamprey, Lampetra japonica.
Melatonin excretion rhythms in the cultured pineal organ of the lamprey, Lampetra japonica.
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培养的七鳃鳗松果体中褪黑激素的排泄节律。
DOI：
10.1159/000109134
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Y. Morita
中科院分区：
文献类型：
--
作者：
M. Samejima;S. Tamotsu;K. Uchida;Y. Moriguchi;Y. Morita
日本七鳃鳗的松果体是维持其昼夜运动节律的重要器官。在本文中，我们试图表明，一个内源性振荡器的位置和工作在松果体。当松果体器官被切除，并在塑料管中与M199培养基在20 ℃下培养时，在光暗和连续黑暗条件下都清楚地观察到褪黑激素分泌节律。在连续黑暗条件下，褪黑素的昼夜分泌持续超过5个周期。这表明松果体有一个内源性振子，褪黑素分泌节律受此振子控制。这些结果表明七鳃鳗的运动活动节律可能受松果体振荡器的控制。
Pineal organ of the lamprey, Lampetra japonica, is essential to keep the circadian locomotor activity rhythm as previously reported. In this paper, we tried to show that an endogenous oscillator is located and is working in the pineal organ. When the pineal organs were excised and cultured in a plastic tube with M199 medium at 20 degrees C, melatonin secretion rhythms were clearly observed under both light-dark and continuous dark conditions. The circadian secretion of melatonin continued for more than five cycles under the continuous dark condition. This indicates that the pineal organ has an endogenous oscillator and that the melatonin secretion rhythm is controlled by this oscillator. These findings suggest the possibility that the locomotor activity rhythm of the lamprey is under the control of the oscillator in the pineal organ.