Sleep disturbance and health-related quality of life in Parkinson's disease: A clear correlation between health-related quality of life and subjective sleep quality
Sleep disturbance and health-related quality of life in Parkinson's disease: A clear correlation between health-related quality of life and subjective sleep quality
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帕金森病患者的睡眠障碍与健康相关生活质量：健康相关生活质量与主观睡眠质量之间的明确相关性
DOI：
10.1016/j.parkreldis.2022.04.014
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发表时间：
2022-05-01
影响因子：
4.1
通讯作者：
Kuriyama，Kenichi
中科院分区：
文献类型：
--
作者：
Tsuru，Ayumi;Matsui，Kentaro;Kuriyama，Kenichi
帕金森病（PD）的共病性失眠和睡眠质量差与健康相关生活质量（HRQoL）差相关。然而，HRQoL与使用多导睡眠图（PSG）获得的睡眠测量之间的关系尚不清楚。我们的目的是研究PD患者各种睡眠测量与HRQoL之间的关系。方法回顾性纳入接受PSG治疗的PD患者，并对包括匹兹堡睡眠质量指数（PSQI）和医疗结果研究36项简短健康调查在内的自填问卷进行问卷调查。结果120例患者平均年龄67.06岁（SD = 8.77），平均Hoehn和Yahr分期2.25岁（SD = 0.78）。PSQI评分越高（主观睡眠质量越差），PSG中睡眠潜伏期越短，N1睡眠越少，N2睡眠越多。多元回归分析显示PSQI总分与身心HRQoL均相关（p<0.001）。然而，两种类型的HRQoL研究都与客观睡眠测量相关，包括睡眠结构指标、睡眠呼吸障碍和睡眠相关运动障碍。结论主观睡眠质量与HRQoL存在相关性，但客观指标与HRQoL的相关性可忽略不计。客观的睡眠碎片可能不会被认为是PD患者的睡眠障碍，因此可能不会对他们的主观健康产生不利影响，因为PSQI评分与睡眠结构之间存在矛盾的相关性。
IntroductionComorbid insomnia and poor sleep quality in Parkinson's disease (PD) are associated with a poor health-related quality of life (HRQoL). However, the relationship between HRQoL and sleep measures obtained using polysomnography (PSG) remains unclear. We aimed to examine the association between various sleep measures and HRQoL in PD patients.MethodsWe retrospectively included patients with PD who underwent PSG and responded to self-administered questionnaires including the Pittsburgh Sleep Quality Index (PSQI) and Medical Outcomes Study 36-Item Short-Form Health Survey.ResultsThe patients' (n = 120) mean age was 67.06 (SD = 8.77) years, and their mean Hoehn and Yahr stage was 2.25 (SD = 0.78). A higher PSQI score (worse subjective sleep quality) was correlated in PSG with shorter sleep latency, less N1 sleep, and more N2 sleep. Multiple regression analysis showed that the total PSQI score correlated with both physical and mental HRQoL (p<0.001 in both cases). However, neither type of HRQoL studied correlated with objective sleep measures, including indicators of sleep architecture, sleep-disordered breathing, and sleep related movement disorders.ConclusionDespite the association between subjective sleep quality and HRQoL, the associations between objective measures and HRQoL were negligible. Objective sleep fragmentation may not be perceived as a sleep disturbance in patients with PD, and therefore may not adversely affect their subjective health, given the paradoxical correlation between PSQI score and sleep architecture.