Autophagy genes mediate the effect of calcineurin on life span in C. elegans
Autophagy genes mediate the effect of calcineurin on life span in C. elegans
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DOI：
10.4161/auto.5.5.8157
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发表时间：
2009-07-01
期刊：
影响因子：
13.3
通讯作者：
Ahnn, Joohong
中科院分区：
文献类型：
--
作者：
Dwivedi, Meenakshi;Song, Hyun-Ok;Ahnn, Joohong
钙调神经磷酸酶(CaN)是一种丝氨酸/苏氨酸磷酸酶，由钙/钙调素(Ca~(2+)/CaM)激活。已知CaN在不同的生物体中调节各种细胞反应。最近的一项研究表明，线虫钙调神经磷酸酶突变体的寿命延长。在这项研究中，我们报告了钙调神经磷酸酶缺陷菌株表现出增强的自噬能力。此外，我们还发现两个必需的自噬基因(bec-1和atg-7)是钙调神经磷酸酶缺失突变体[CNB-1(Jh103)]延长寿命所必需的。因此，我们首次提出自噬基因对于钙调神经磷酸酶缺陷的线虫株的寿命调节是必需的。
Calcineurin (CaN) is a serine/threonine phosphatase, activated by Ca2+/calmodulin (Ca2+/CaM). CaN is known to regulate various cellular responses in different organisms. A recent study showed an extended life span in the calcineurin mutants of C elegans. In this study, we report that calcineurin defective strains exhibit enhanced autophagy. In addition, we found two essential autophagy genes (bec-1 and atg-7) are required for the life-span extension in calcineurin null mutants [cnb-1(jh103)]. Thus, for the first time we suggest that autophagy genes are required for the life-span regulation in calcineurin defective C. elegans strains.