Left ventricular-based cardiac stimulation post AV nodal ablation evaluation (The PAVE study)
Left ventricular-based cardiac stimulation post AV nodal ablation evaluation (The PAVE study)
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DOI：
10.1111/j.1540-8167.2005.50062.x
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发表时间：
2005-11-01
影响因子：
2.7
通讯作者：
Pires, LA
中科院分区：
文献类型：
--
作者：
Doshi, RN;Daoud, EG;Pires, LA
PAVE研究：背景：据报道，慢性右心室起搏可促进心脏不同步。PAVE试验前瞻性地比较了慢性双心室起搏右心室起搏的患者接受消融的AV结管理房颤与快速ventricular rates.Methods和结果：184例需要AV结消融的患者随机接受双心室起搏系统（n = 103）或右心室起搏系统（n = 81）。研究终点为6分钟走廊步行试验、生活质量和左心室射血分数的变化。患者特征相似（64%为男性;年龄：69 ± 10岁，射血分数：0.46 ± 0.16; 83%，NYHA II级或III级）。消融术后6个月，接受心脏起搏治疗的患者6分钟步行距离显著改善（31%），高于基线（82.9 +/- 94.7 m），而接受右心室起搏治疗的患者6分钟步行距离显著改善（24%），高于基线（61.2 +/- 90.0 m）（P = 0.04）。生活质量参数无显著差异。消融术后6个月，双心室组的射血分数（0.46 +/- 0.13）显著高于接受右心室起搏的患者（0.41 +/- 0.13，P = 0.03）。射血分数患者
PAVE Study.Background: Chronic right ventricular pacing has been reported to promote cardiac dyssynchrony. The PAVE trial prospectively compared chronic biventricular pacing to right ventricular pacing in patients undergoing ablation of the AV node for management of atrial fibrillation with rapid ventricular rates.Methods and Results: One hundred and eighty-four patients requiring AV node ablation were randomized to receive a biventricular pacing system (n = 103) or a right ventricular pacing system (n = 81). The study endpoints were change in the 6-minute hallway walk test, quality of life, and left ventricular ejection fraction. Patient characteristics were similar (64% male; age: 69 +/- 10 years, ejection fraction: 0.46 +/- 0.16; 83%, NYHA Class II or III). At 6 months postablation, patients treated with cardiac resynchronization had a significant improvement in 6-minute walk distance, (31%) above baseline (82.9 +/- 94.7 m), compared to patients receiving right ventricular pacing, (24%) above baseline (61.2 +/- 90.0 m) (P = 0.04). There were no significant differences in the quality-of-life parameters. At 6 months postablation, the ejection fraction in the biventricular group (0.46 +/- 0.13) was significantly greater in comparison to patients receiving right ventricular pacing (0.41 +/- 0.13, P = 0.03). Patients with an ejection fraction