Association of Immunoglobulin-like Transcript 6 Deficiency With Sjogren's Syndrome
Association of Immunoglobulin-like Transcript 6 Deficiency With Sjogren's Syndrome
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DOI：
10.1002/art.24804
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发表时间：
2009-10-01
影响因子：
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通讯作者：
Witte, T.
中科院分区：
文献类型：
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作者：
Kabalak, G.;Dobberstein, S. B.;Witte, T.
目标。免疫球蛋白样转录物（ILT）家族位于染色体19q13区，由一组激活和抑制受体组成。ILT受体在抗原呈递细胞（巨噬细胞、树突状细胞、B淋巴细胞）以及T细胞和自然杀伤细胞上表达。ILT2和ILT4在耐受性诱导中起作用，ILT3已被证明可诱导Treg细胞。ILT6的纯合缺失已被证明与多发性硬化症有关。由于ILT6可能是免疫系统的一种调节剂，我们进行了这项研究，以研究ILT6缺乏与干燥综合征（SS）的关系。我们对149名SS患者和749名健康对照进行了基因分型，采用聚合酶链反应检测ilt6的存在与否。在8%的SS患者中检测到纯合子ILT6缺乏症，而在对照组中仅检测到3%。我们的研究结果表明，ILT6缺乏可能是SS的遗传危险因素。
Objective. The immunoglobulin-like transcript (ILT) family is located in chromosomal region 19q13 and consists of a group of activating and inhibitory receptors. The ILT receptors are expressed on antigen-presenting cells (macrophages, dendritic cells, B lymphocytes), as well as on T cells and natural killer cells. ILT2 and ILT4 play a role in tolerance induction, and ILT3 has been shown to induce Treg cells. A homozygous deletion of ILT6 has been shown to be associated with multiple sclerosis. Since ILT6 may be a modulator of the immune system, we undertook this study to examine the association of ILT6 deficiency with Sjogren's syndrome (SS).Methods. We genotyped 149 patients with SS and 749 healthy controls, using polymerase chain reaction to test for the presence or absence of ILT6.Results. Homozygous ILT6 deficiency was detected in 8% of SS patients and in only 3% of controls.Conclusion. Our findings indicate that ILT6 deficiency may be a genetic risk factor for SS.