Relation of regional articular cartilage morphometry and meniscal position by MRI to joint space width in knee radiographs
Relation of regional articular cartilage morphometry and meniscal position by MRI to joint space width in knee radiographs
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DOI：
10.1016/j.joca.2009.04.001
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发表时间：
2009-09-01
影响因子：
7
通讯作者：
Le Graverand, M. P. Hellio
中科院分区：
文献类型：
--
作者：
Hunter, D. J.;Buck, R.;Le Graverand, M. P. Hellio
目的：探讨膝关节软骨形态测量和半月板位置对膝关节Lyon Schuss X线片测量关节间隙宽度(JSW)的影响。设计：对62例肥胖膝关节骨性关节炎患者和99例非肥胖女性对照(平均年龄56.6岁)进行3T磁共振成像和冠状水激发破坏梯度回波序列成像。使用定制软件进行股骨胫骨软骨形态分割和局部形态计量分析。在矢状面和冠状面对半月板位置进行定量测量。最小间隙宽度(MJSW)在Lyon Schuss膝关节X线片上测量；Kellgren和Lawrence分级(KLG)在立位膝关节正位X线片上被分配。结果：区域软骨厚度测量、不同的KLG和半月板覆盖范围可以解释mJSW的65%的变异。在这些测量中，胫骨内侧软骨厚度测量和股骨中央内侧区域(CCMF)在所有KLG观察到的mJSW变化中起着一致的作用。此外，CCMF和半月板覆盖率的增加解释了关节间隙有一定狭窄(KLG3)的受试者和没有关节间隙狭窄的受试者之间的平均mJSW值的差异。结论：用5个区域软骨厚度测量和半月板覆盖率最好地描述了放射学mJSW值的变化。每项指标的贡献大小根据放射学严重程度的不同而不同，更多的变异性由CCMF的软骨厚度、软骨厚度和半月板复盖率来解释，病情越严重。(C)2009年国际骨性关节炎研究会。爱思唯尔有限公司出版。保留所有权利。
Objective: To ascertain the contribution of articular cartilage morphometry and meniscal position on MRI to joint space width (JSW) measured in the Lyon schuss radiograph of the knee.Design: 62 obese women with knee OA and 99 non-obese female controls (mean age 56.6 years) were imaged using 3 T MRI and coronal water excitation spoiled gradient echo sequences. Segmentation of femorotibial cartilage morphology and regional morphometric analysis was performed using custom software. Meniscal position was measured quantitatively in sagittal and coronal planes. Minimum space width (mJSW) was measured in the Lyon Schuss knee radiograph; Kellgren and Lawrence grades (KLG) were assigned on standing anteroposterior knee films. The relative contribution of regional cartilage thickness and meniscal position to mJSW was assessed initially in univariate models and subsequently with multivariable modelling.Results: 65% of the variation in mJSW was explained by regional cartilage thickness measures, different KLG and meniscal coverage. Of these measures the medial tibia cartilage thickness measures and central region of the central medial femur (ccMF) play a consistent role in variations in mJSW observed across all KLG. Further ccMF and the addition of percent meniscal coverage to this model explains the remaining differences in mean mJSW found between those subjects with definite joint space narrowing (KLG3) and those without OA.Conclusion: The variation in radiographic mJSW is best described by five regional cartilage thickness measures and percent meniscal coverage. The magnitude of each measures contribution differs according to radiographic severity with more variability explained by cartilage thickness of ccMF cartilage thickness and percent meniscal coverage with more severe disease. (C) 2009 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.