The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model.
The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model.
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DOI：
10.1038/s42003-022-03171-9
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发表时间：
2022-03-10
影响因子：
5.9
通讯作者：
Nougairède A
中科院分区：
文献类型：
--
作者：
Cochin M;Luciani L;Touret F;Driouich JS;Petit PR;Moureau G;Baronti C;Laprie C;Thirion L;Maes P;Boudewijns R;Neyts J;de Lamballerie X;Nougairède A
2020年底，SARS-CoV-2 Alpha变种在英国出现，并逐渐取代最初参与全球大流行传播的G614菌株。在这项研究中，我们使用叙利亚仓鼠模型比较临床菌株的α变体与祖先G614菌株。α变体成功感染动物并诱导模拟COVID-19的病理学。然而，这两种菌株复制到几乎相同的水平，并诱导了相当的疾病和免疫反应。在竞争和传播实验中，G614菌株具有轻微的适应性优势。该等数据并未证实二零二一年上半年在人类中观察到的流行病学情况，亦未证实有报告显示α变体在人类重建支气管上皮中复制更快。这项研究强调了需要联合收割机数据从不同的实验室使用各种动物模型来破译新出现的SARS-CoV-2变异的生物学特性。在叙利亚仓鼠模型中，SARS-CoV-2 α变异体表现出与祖先D614 G变异体相似的传播动力学，这表明使用仓鼠作为唯一模型来评估SARS-CoV-2毒株之间的差异存在局限性。
Late 2020, SARS-CoV-2 Alpha variant emerged in United Kingdom and gradually replaced G614 strains initially involved in the global spread of the pandemic. In this study, we use a Syrian hamster model to compare a clinical strain of Alpha variant with an ancestral G614 strain. The Alpha variant succeed to infect animals and to induce a pathology that mimics COVID-19. However, both strains replicate to almost the same level and induced a comparable disease and immune response. A slight fitness advantage is noted for the G614 strain during competition and transmission experiments. These data do not corroborate the epidemiological situation observed during the first half of 2021 in humans nor reports that showed a more rapid replication of Alpha variant in human reconstituted bronchial epithelium. This study highlights the need to combine data from different laboratories using various animal models to decipher the biological properties of newly emerging SARS-CoV-2 variants. The SARS-CoV-2 Alpha variant exhibits similar transmission dynamics to an ancestral D614G variant in a Syrian hamster model, suggesting the limitations of using the hamster as the sole model to assess differences between SARS-CoV-2 strains.
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影响因子：
6.7
作者：
de Fabritus, Lauriane;Nougairede, Antoine;de Lamballerie, Xavier
通讯作者：
de Lamballerie, Xavier
影响因子：
64.8
作者：
Plante JA;Liu Y;Liu J;Xia H;Johnson BA;Lokugamage KG;Zhang X;Muruato AE;Zou J;Fontes-Garfias CR;Mirchandani D;Scharton D;Bilello JP;Ku Z;An Z;Kalveram B;Freiberg AN;Menachery VD;Xie X;Plante KS;Weaver SC;Shi PY
通讯作者：
Shi PY
DOI：
10.1016/s0140-6736(21)00183-5
发表时间：
2021-02-06
期刊：
Lancet (London, England)
影响因子：
--
作者：
Sabino EC;Buss LF;Carvalho MPS;Prete CA Jr;Crispim MAE;Fraiji NA;Pereira RHM;Parag KV;da Silva Peixoto P;Kraemer MUG;Oikawa MK;Salomon T;Cucunuba ZM;Castro MC;de Souza Santos AA;Nascimento VH;Pereira HS;Ferguson NM;Pybus OG;Kucharski A;Busch MP;Dye C;Faria NR
通讯作者：
Faria NR
影响因子：
16.6
作者：
Driouich JS;Cochin M;Lingas G;Moureau G;Touret F;Petit PR;Piorkowski G;Barthélémy K;Laprie C;Coutard B;Guedj J;de Lamballerie X;Solas C;Nougairède A
通讯作者：
Nougairède A
DOI：
10.1016/s2468-2667(21)00055-4
发表时间：
2021-05
期刊：
The Lancet. Public health
影响因子：
--
作者：
Graham MS;Sudre CH;May A;Antonelli M;Murray B;Varsavsky T;Kläser K;Canas LS;Molteni E;Modat M;Drew DA;Nguyen LH;Polidori L;Selvachandran S;Hu C;Capdevila J;COVID-19 Genomics UK (COG-UK) Consortium;Hammers A;Chan AT;Wolf J;Spector TD;Steves CJ;Ourselin S
通讯作者：
Ourselin S