A conceptual framework of frailty: A review
A conceptual framework of frailty: A review
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DOI：
10.1093/gerona/57.5.m283
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发表时间：
2002-05-01
影响因子：
5.1
通讯作者：
Bortz, WM
中科院分区：
文献类型：
--
作者：
Bortz, WM
这篇文章概述了日益普遍的脆弱状况，这一状况基本上缺乏明确的定义。各种来源提供了关于定义、发生率、原因、发生率和出现时间的陈述。利用新阐述的共态过程，解释了继发于能量负荷变化的结构和功能的共同适应，我提出脆弱是一组全身范围的相关恶化，包括但不限于肌肉骨骼、心血管、代谢和免疫系统。导致这一系列发现的共同最终途径通常与身体活动减少有关，要么是习惯的结果，要么是疾病的影响。因此，脆弱状态在很大程度上可以从衰老过程中分离出来，因此应该容易受到积极的干预和逆转。
This article presents an overview of the increasingly common condition of frailty, which by and large lacks clarity of definition. A variety of sources provide this statement regarding definition, incidence, causation, rate, and time of appearance. Utilizing the newly elaborated process of symmorphosis, which explains the coadaptation of structure and function secondary to altered energy loads, I propose that frailty is a body-wide set of linked deteriorations including, but not confined to, musculoskeletal, cardiovascular, metabolic, and immunologic systems. The common final pathway that leads to this constellation of findings is usually keyed to a decline in physical activity either as a result of habit or disease inputs. As such, the state of frailty is largely separable from the process of aging and should thereby be susceptible to active intervention and reversal.