Versatile T1-Based Chemical Analysis Platform Using Fe3+/Fe2+ Interconversion
Versatile T1-Based Chemical Analysis Platform Using Fe3+/Fe2+ Interconversion
复制标题
使用 Fe3 /Fe2 互变的基于 T-1 的多功能化学分析平台
DOI：
10.1021/acs.analchem.7b03961
复制
发表时间：
2018-01-16
影响因子：
7.4
通讯作者：
Jiang, Xingyu
中科院分区：
文献类型：
--
作者：
Chen, Yiping;Yin, Binfeng;Jiang, Xingyu
We report a versatile analytical platform for assaying multiple analytes relying on changes in longitudinal relaxation time (T-1) as a result of Fe3+/Fe2+ interconversion. The T-1 of water protons in Fe3+ aqueous solution differs significantly from that of Fe2+, allowing for the development of a generally applicable Trbased assay since many redox reactions enable the interconversion between Fe' and Fe3+ that can result in the change of Ti. Compared with conventional magnetic biosensors, this T-1-based assay is free of magnetic nanoparticles (MNPs), and the stability of T-1 based assay is better than conventional magnetic sensors that suffer from nonspecific adsorption and aggregation of MNPs. This T-1-based assay simultaneously enables "one-step mixing" assays (such as saliva sugar) and "multiple-washing" immunoassays with good stability and sensitivity, offering a promising platform for convenient, stable, and versatile biomedical analysis
