Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm
Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm
复制标题
DOI：
10.1167/iovs.15-16670
复制
发表时间：
2015-10-01
影响因子：
4.4
通讯作者：
Wolf, Armin
中科院分区：
文献类型：
--
作者：
Mohler, Kathrin J.;Draxinger, Wolfgang;Wolf, Armin
目的.旨在证明在类似于60度的视场内，正常和患病眼睛脉络膜成像的超高速扫频源光学相干断层扫描（SS-OCT）为168万次A扫描/s。研究并关联宽视野三维（3D）脉络膜厚度（ChT）和血管模式，使用ChT图和从单个密集采样的兆赫-OCT（MHz-OCT）探头中提取的共配准高清晰度正面图像。使用基于傅里叶域锁模激光器的1.68 MHz原型SS-OCT系统在1050 nm处采集了由2088 x 1024 A扫描组成的高清、类似于60度宽场3D数据集。九个主题（九只眼睛）与各种脉络膜视网膜疾病或无眼部病理。共配准的ChT地图，脉络膜总和地图，和深度分辨的正面图像参考视网膜色素上皮或脉络膜-巩膜界面使用手动分割。宽场ChT地图显示，在外周和中央ChT的大的个体间和个体内的方差。在9只眼睛中，只有4只眼睛的ChT最大的位置与中央凹重合。脉络膜外的大腔血管的解剖结构似乎在确定全球ChT模式中起着重要作用。在一些眼睛中观察到具有大厚度梯度的局灶性ChT变化。不同的ChT和血管模式可以可视化超过60度的患者首次使用OCT。由于局灶性ChT的变化，高密度的厚度测量可能是有利的。高清晰度深度分辨正面图像是对横截面和厚度图的补充，并增强了对不同ChT模式的解释。
PURPOSE. To demonstrate ultrahigh-speed swept-source optical coherence tomography (SS-OCT) at 1.68 million A-scans/s for choroidal imaging in normal and diseased eyes over a similar to 60 degrees field of view. To investigate and correlate wide-field three-dimensional (3D) choroidal thickness (ChT) and vascular patterns using ChT maps and coregistered high-definition en face images extracted from a single densely sampled Megahertz-OCT (MHz-OCT) dataset.METHODS. High-definition, similar to 60 degrees wide-field 3D datasets consisting of 2088 x 1024 A-scans were acquired using a 1.68 MHz prototype SS-OCT system at 1050 nm based on a Fourier-domain mode-locked laser. Nine subjects (nine eyes) with various chorioretinal diseases or without ocular pathology are presented. Coregistered ChT maps, choroidal summation maps, and depth-resolved en face images referenced to either the retinal pigment epithelium or the choroidal-scleral interface were generated using manual segmentation.RESULTS. Wide-field ChT maps showed a large inter-and intraindividual variance in peripheral and central ChT. In only four of the nine eyes, the location with the largest ChT was coincident with the fovea. The anatomy of the large lumen vessels of the outer choroid seems to play a major role in determining the global ChT pattern. Focal ChT changes with large thickness gradients were observed in some eyes.CONCLUSIONS. Different ChT and vascular patterns could be visualized over similar to 60 degrees in patients for the first time using OCT. Due to focal ChT changes, a high density of thickness measurements may be favorable. High-definition depth-resolved en face images are complementary to cross sections and thickness maps and enhance the interpretation of different ChT patterns.