FACTORS INFLUENCING RATE OF AGING OF A SERIES ALKYL METHYLPHOSPHONYL-ACETYLCHOLINESTERASES
FACTORS INFLUENCING RATE OF AGING OF A SERIES ALKYL METHYLPHOSPHONYL-ACETYLCHOLINESTERASES
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DOI：
10.1042/bj1000572
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发表时间：
1966-01-01
影响因子：
4.1
通讯作者：
DAVIES, DR
中科院分区：
文献类型：
--
作者：
BERRY, WK;DAVIES, DR
1.当烷基是伯醇时，无论碳链是否支化，一系列烷基甲基膦酰基-乙酰胆碱酯酶表现出的对肟再活化的抗性（“老化”）的逐渐发展是缓慢的，但如果烷基是仲醇或环状醇，则要快得多。 2.温度升高或pH值降低会加速老化。 3、季胺N-甲基碘化吡啶抑制老化。 4.讨论了与衰老在有机磷化合物中毒治疗中所起的作用有关的结果。
1. The progressive development of resistance to reactivation by an oxime (`aging') shown by a series of alkyl methylphosphonyl-acetylcholinesterases is slow when the alkyl group is a primary alcohol, whether or not the carbon chain is branched, but is much more rapid if the alkyl group is a secondary or cyclic alcohol. 2. Aging is accelerated by increase of temperature or decrease of pH. 3. Aging is inhibited by the quaternary amine N-methylpyridinium iodide. 4. The results are discussed in relation to the role played by aging in the therapy of poisoning by organophosphorus compounds.