Lifetime consumption of alcoholic beverages and risk of 13 types of cancer in men: Results from a case-control study in Montreal
Lifetime consumption of alcoholic beverages and risk of 13 types of cancer in men: Results from a case-control study in Montreal
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DOI：
10.1016/j.canep.2009.03.001
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发表时间：
2009-01-01
影响因子：
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通讯作者：
Siemiatycki, Jack
中科院分区：
文献类型：
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作者：
Benedetti, Andrea;Parent, Marie-Elise;Siemiatycki, Jack
背景：这项研究的目的是调查终生饮用酒精饮料与癌症风险之间的关系。研究方法：1980年代中期在蒙特利尔进行的一项以人口为基础的病例对照研究收集了数据，旨在评估数百种非职业和职业暴露与男性多个癌症部位之间的关系。我们展示了13个癌症部位的结果：食管（n = 78）、胃（n = 215）、结肠（n = 427）、直肠（n = 239）、肝（n = 28）、胰腺（n = 83）、肺（n = 700）、黑色素瘤（n = 107）、前列腺（n = 374）、膀胱（n = 425）、肾（n = 156），霍奇金淋巴瘤（n = 42）和非霍奇金淋巴瘤（n = 190），与对照组（n = 507）相比。估计总酒精饮料，啤酒，葡萄酒和/或烈酒，alto-ether和单独的终身消费量与每个癌症部位之间的关联的比值比（OR），同时使用多分类logistic回归仔细调整吸烟和其他协变量。结果如下：对于几种癌症（食道癌，胃癌，结肠癌，肝癌，胰腺癌，肺癌，前列腺癌），有证据表明，与戒酒者和偶尔饮酒者相比，饮酒者的风险增加。对于大多数网站来说，是啤酒和较小程度上的烈酒消费推动了超额风险。结论：我们的研究结果支持这一假设，即一生中中度和高度的酒精摄入水平可能会增加几个部位的癌症风险。(C)2009爱思唯尔有限公司保留所有权利。
Background: The aim of the study was to investigate the association between lifetime consumption of alcoholic beverages and cancer risk. Methods: Data were collected in a population-based case-control study, conducted in Montreal in the mid-1980s, designed to assess the associations between hundreds of non-occupational and occupational exposures and multiple cancer sites in men. We present results for 13 cancer sites: oesophagus (n = 78), stomach (n = 215), colon (n = 427), rectum (n = 239), liver (n = 28), pancreas (n = 83), lung (n = 700), melanoma (n = 107), prostate (n = 374), bladder (n = 425), kidney (n = 156), Hodgkin's lymphoma (n = 42), and non-Hodgkin's lymphoma (n = 190), in comparison to population controls (n = 507). Odds ratios (OR) were estimated for the associations between lifetime consumption of total alcoholic beverages, beer, wine, and/or spirits, alto-ether and separately, and each cancer site, while carefully adjusting for smoking and other covariates using polytomous logistic regression. Results: For several cancers (oesophagus, stomach, colon, liver, pancreas, lung, prostate) there was evidence of increased risk among alcohol consumers compared with abstainers and occasional drinkers. For most sites, it was beer and to a lesser extent spirits consumption that drove the excess risks. Conclusions: Our results support the hypothesis that moderate and high alcohol intake levels over the lifetime might increase cancer risk at several sites. (C) 2009 Elsevier Ltd. All rights reserved.