QUANTITATIVE NMR MEASUREMENTS OF HIPPOCAMPAL ATROPHY IN ALZHEIMER-DISEASE
QUANTITATIVE NMR MEASUREMENTS OF HIPPOCAMPAL ATROPHY IN ALZHEIMER-DISEASE
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DOI：
10.1002/mrm.1910080210
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发表时间：
1988-10-01
影响因子：
3.3
通讯作者：
BUDINGER, TF
中科院分区：
文献类型：
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作者：
SEAB, JP;JAGUST, WJ;BUDINGER, TF
应用核磁共振（NMR）成像技术对10例阿尔茨海默病（AD）患者和7例健康老年人进行了研究。冠状切片用于海马、脑室、蛛网膜下腔和脑实质的体积测量。与对照组相比，AD组的海马体积（相对于豆状核大小标准化）减少了40%，两组之间没有重叠。脑萎缩以及脑室和脑沟扩大的总体测量结果也显示出显著不同的组平均值，尽管两组之间存在重叠。海马萎缩与整体脑萎缩或痴呆严重程度无关，尽管脑萎缩程度与痴呆严重程度相关。这些结果表明，NMR能够提供AD中海马大小减少的体内定量，这与总体脑萎缩无关，并且可以将AD与正常老化区分开。
Nuclear magnetic resonance (NMR) imaging was employed to study 10 patients with Alzheimer''s disease (AD) and seven healthy elderly control subjects. Coronal sections were used to make volumetric measurements of the hippocampus, ventricles, subarachnoid space, and brain parenchyma. The hippocampal volume (normalized relative to the size of the lenticular nucleus) was reduced by 40% in the AD group compared to the controls, with no overlap between the two groups. Overall measures of brain atrophy and ventricular and sulcal enlargement also showed significantly different groups means, although with overlap between the two groups. Hippocampal atrophy did not correlate with either overall brain atrophy or dementia severity, although the degree of brain atrophy was correlated with dementia severity. These results show that NMR is capable of providing in vivo quantification of diminished hippocampal size in AD which is not correlated with overall brain atrophy and which may differentiate AD from normal aging.