Alloimmune-mediated vascular remodeling of human coronary artery grafts in immunodeficient mouse recipients is independent of preexisting atherosclerosis.
Alloimmune-mediated vascular remodeling of human coronary artery grafts in immunodeficient mouse recipients is independent of preexisting atherosclerosis.
复制标题
在免疫缺陷小鼠受体中，同种免疫介导的人冠状动脉移植血管重塑与先前存在的动脉粥样硬化无关。
DOI：
10.1097/01.tp.0000264560.51845.67
复制
发表时间：
2007
期刊：
影响因子：
6.2
通讯作者：
Tellides,George
中科院分区：
文献类型：
--
作者：
Wang,Yinong;Ahmad,Usman;Yi,Tai;Zhao,Liping;Lorber,MarcI;Pober,JordanS;Tellides,George
血管重塑而不是内膜增厚是心脏移植动脉硬化管腔损失的最重要决定因素。在实验环境中，供体传播的动脉粥样硬化病变对同种免疫介导的动脉损伤的影响尚不清楚。我们在用同种异体人外周血单核细胞重建的免疫缺陷小鼠受体的人冠状动脉移植嵌合模型中研究了这个问题。排斥移植物表现出强劲的内膜扩张、向外的血管重塑和可变的管腔损失。动脉供体先前存在的动脉粥样硬化、性别和年龄与同种免疫诱导的血管形态变化程度之间没有显着关系。我们的实验结果是在一个没有免疫抑制药物潜在混杂变量的系统中，与大多数临床研究一致，即同种免疫介导的内膜损伤和血管重塑与先前存在的冠状动脉粥样硬化无关。我们的结果支持扩大器官捐献者标准以包括轻度冠状动脉粥样硬化的概念。
Vascular remodeling rather than intimal thickening is the most important determinant of luminal loss in cardiac graft arteriosclerosis. The impact of donor-transmitted atherosclerotic lesions on alloimmune-mediated arterial injury in an experimental setting is not known. We investigated this issue in a chimeric model of human coronary artery grafts to immunodeficient mouse recipients reconstituted with allogeneic human peripheral blood mononuclear cells. Rejecting grafts demonstrated robust intimal expansion, outward vascular remodeling, and variable lumen loss. There was no significant relationship between preexistent atherosclerosis, gender, and age of the artery donors vs. the degree of alloimmune-induced changes in vessel morphology. Our experimental findings, in a system without the potentially confounding variable of immunosuppressive drugs, are in agreement with the majority of clinical studies that alloimmune-mediated intimal injury and vascular remodeling is independent of preexisting coronary atherosclerosis. Our results support the concept of extending the criteria for organ donors to include modest coronary atherosclerosis.