PATHOLOGY OF SHY‐DRAGER SYNDROME*
PATHOLOGY OF SHY‐DRAGER SYNDROME*
复制标题
SHY-DRAGER 综合征的病理学*
DOI：
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发表时间：
1978
影响因子：
3.2
通讯作者：
E. Segal
中科院分区：
文献类型：
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作者：
J. Sung;A. Mastri;E. Segal
在四例患者的Shy-Drager综合征，详细的病理结果在中枢神经系统的描述。所有4例患者均有纹状体黑质变性、橄榄脑桥小脑萎缩、锥体束变性和腹角细胞丢失。沿着多系统变性，胸腰段自主神经元广泛缺失，这通过4例患者中2例的中间外侧角的比较细胞计数证实。在所有4例患者中，骶髓的自主神经核，特别是Onuf核和中间外侧核，受到严重影响，核中弥漫性细胞丢失似乎是Shy-Drager综合征膀胱、直肠和性功能紊乱的原因。
In four patients with the Shy-Drager syndrome, detailed pathological findings in the central nervous system are described. All four patients had striatonigral degeneration, olivopontocerebellar atrophy, pyramidal tract degeneration and ventral horn cell loss. Along with the multisystem degeneration, there was widespread loss of thoracolumbar autonomic neurons, which was demonstrated by comparative cell counts of the intermediolateral horns in two of the four patients. In all four patients, autonomic nuclei of the sacral cord, particularly the Onuf's and intermediolateral nuclei, were severely affected and diffuse cell loss in the nuclei seems to account for disordered bladder, rectal and sexual functions in Shy-Drager syndrome.