Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria
Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria
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DOI：
10.4269/ajtmh.2008.78.198
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发表时间：
2008-02-01
影响因子：
3.3
通讯作者：
Boivin, Michael J.
中科院分区：
文献类型：
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作者：
John, Chandy C.;Panoskaltsis-Mortari, Angela;Boivin, Michael J.
研究人员测量了 76 名乌干达脑型疟疾 (CM) 儿童和 8 名对照儿童的脑脊液 (CSF) 和血清中 12 种对中枢神经系统 (CNS) 感染重要的细胞因子或趋化因子的水平。与对照儿童相比，脑型疟疾儿童脑脊液中白细胞介素（IL）-6、CXCL-8/IL-8、粒细胞集落刺激因子（G-CSF）、肿瘤坏死因子-α（TNF-α）和IL-1受体拮抗剂的水平较高。除 G-CSF 外，任何细胞因子的脑脊髓和血清细胞因子水平之间均不存在相关性。脑脊液升高，但血清 TNF-a 不升高。入院时的水平与 3 个月后神经功能缺陷的风险增加相关（比值比 1.55，95% CI：1.10，2.18，P = 0.01），并与年龄调整后的注意力评分（Spearman rho，-0.34，P = 0.04）和工作记忆评分（Spearman rho，-0.32，P = 0.06）6 个月呈负相关。稍后。在患有脑型疟疾的儿童中，中枢神经系统 TNF-α 的产生与随后的神经系统和认知疾病相关。
Cerebrospinal fluid (CSF) and serum levels of 12 cytokines or chemokines important in central nervous system (CNS) infections were measured in 76 Ugandan children with cerebral malaria (CM) and 8 control children. As compared with control children, children with cerebral malaria had higher cerebrospinal fluid levels of interleukin (IL)-6, CXCL-8/IL-8, granulocyte-colony stimulating factor (G-CSF), tumor necrosis factor-alpha (TNF-alpha), and IL-1 receptor antagonist. There was no correlation between cerebrospinal and serum cytokine levels for any cytokine except G-CSF. Elevated cerebrospinal fluid but not serum TNF-a. levels on admission were associated with an increased risk of neurologic deficits 3 months later (odds ratio 1.55, 95% CI: 1.10, 2.18, P = 0.01) and correlated negatively with age-adjusted scores for attention (Spearman rho, -0.34, P = 0.04) and working memory (Spearman rho, -0.32, P = 0.06) 6 months later. In children with cerebral malaria, central nervous system TNF-alpha production is associated with subsequent neurologic and cognitive morbidity.