Interleukin-10 as a predictor of major adverse cardiovascular events in a racially and ethnically diverse population: Multi-Ethnic Study of Atherosclerosis
Interleukin-10 as a predictor of major adverse cardiovascular events in a racially and ethnically diverse population: Multi-Ethnic Study of Atherosclerosis
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DOI：
10.1016/j.annepidem.2018.08.013
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发表时间：
2019-02-01
影响因子：
5.6
通讯作者：
Seeman, Teresa
中科院分区：
文献类型：
--
作者：
Goldwater, Deena;Karlamangla, Arun;Seeman, Teresa
目的：了解抗炎细胞因子白介素10(IL-10)的基线水平是否与亚临床动脉粥样硬化或不良心血管事件的风险相关。方法：本研究包括930名来自动脉粥样硬化多种族研究(MESA)辅助应激研究的成年人。参与者在注册时年龄在48-90岁之间，平均跟踪时间为10.2年。在最初的应激研究访问中测定IL-10水平。心血管结果被定义为复合心血管死亡、心肌梗死、中风、中风死亡和复苏的心脏骤停。采用Agatston冠状动脉钙化评分(CAC)测定冠状动脉钙化程度。用COX比例风险模型评价IL-10水平与心血管事件风险的关系，用流行风险比(PRR)和线性回归模型分析1L-10水平与CAC的存在和数量的关系。结果：完全校正后，IL-10水平不能预测心血管事件(HR 1.19，95%CI 0.89，1.60)，与CAC患病率(PRR 1.00，95%CI 0.94，1.07)和CAC数量(β-0.01，95%CI-0.23，0.21)不相关。结论：在无临床心脏病的个体中，基线IL-10水平与心血管事件的风险无关，是一个较差的亚临床冠状动脉粥样硬化标志物。(C)2018 Elsevier Inc.保留所有权利。
Purpose: To understand if baseline levels of the anti-inflammatory cytokine interleukin-10 (IL-10) are associated with either subclinical atherosclerosis or risk for adverse cardiovascular (CV) events.Methods: The study included 930 adults from the Multi-Ethnic Study of Atherosclerosis (MESA) ancillary Stress Study. Participants, age 48-90 years at enrollment, were followed for an average of 10.2 years. IL-10 level was measured at the initial Stress Study visit. Cardiovascular outcomes were defined as composite CV death, myocardial infarction, stroke, stroke death, and resuscitated cardiac arrest. Coronary calcification was determined by Agatston coronary artery calcium (CAC) score. The association between IL-10 level and CV event risk was evaluated by Cox proportional hazard modeling, while that of 1L-10 level and CAC presence and amount was determined with prevalence risk ratio (PRR) and linear regression modeling, respectively. Models were adjusted for CV risk factors and proinflammatory biomarkers.Results: After full adjustment, IL-10 level did not predict CV events (HR 1.19, 95%CI 0.89, 1.60) and was not associated with CAC prevalence (PRR 1.00, 95%Cl 0.94, 1.07), nor amount of CAC in those with nonzero CAC (beta -0.01, 95%CI -0.23, 0.21).Conclusion: In individuals without clinical heart disease, baseline IL-10 level appears unrelated to risk of CV events and is a poor marker of subclinical coronary atherosclerosis. (C) 2018 Elsevier Inc. All rights reserved.