Subjective fatigue is not associated with cognitive impairment in multiple sclerosis: cross-sectional and longitudinal analysis
Subjective fatigue is not associated with cognitive impairment in multiple sclerosis: cross-sectional and longitudinal analysis
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DOI：
10.1177/1352458509106213
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发表时间：
2009-08-01
影响因子：
5.8
通讯作者：
Benedict, R. H. B.
中科院分区：
文献类型：
--
作者：
Morrow, S. A.;Weinstock-Guttman, B.;Benedict, R. H. B.
背景 多发性硬化症 (MS) 的研究报告了关于疲劳和认知的相互矛盾的结论，部分原因可能是由于使用了小样本量和经常依赖横断面方法。目的 为了正确评估和治疗多发性硬化症患者，区分这两种致残症状的能力是必要的。方法在回顾性分析中，我们使用横断面方法 (n = 465) 和纵向方法 (n = 69）。使用称为多发性硬化症认知功能最低限度评估（MACFIMS）的综合系统来测量认知，并使用疲劳严重程度量表（FSS）来测量疲劳程度。 FSS 分数被归类为正常 (= 5.0)。重复评估 (n = 69) 根据 FSS 0.5 或 1.0 的变化分为改善或恶化。结果 MS 患者的 FSS 评分显着高于正常对照 (P < 0.001)。在横断面或纵向分析中，未发现 FSS 和 NP 评分之间存在相关性。使用贝克抑郁量表快速筛查 (BDIFS) 进行评估，疲劳与抑郁呈中度相关（r = 0.44，P < 0.001）。纵向来看，FSS 和 BDIFS 的变化之间存在中等相关性（r = 0.34，P = 0.001），但使用任一变化定义的 NP 评分均无显着差异。 结论 我们得出的结论是，自我报告的疲劳虽然与自我报告的抑郁相关，但与 MS 的认知能力没有显着相关。多发性硬化症2009； 15：998-1005。 http://msj.sagepub.com
Background Studies in multiple sclerosis (MS) report conflicting conclusions regarding fatigue and cognition, which may partly be due to the use of small sample sizes and frequent reliance on a cross-sectional approach.Objective The ability to distinguish between these two disabling symptoms is necessary in order to properly assess and treat MS patients.Methods In a retrospective analysis, we assessed the correlation between fatigue and neuropsychological (NP) testing using a cross-sectional (n = 465) and longitudinal approach (n = 69). Cognition was measured using a comprehensive battery called the Minimal Assessment of Cognitive Function in MS (MACFIMS), and fatigue was measured with the Fatigue Severity Scale (FSS). FSS scores were categorized as normal (= 5.0). Repeat assessments (n = 69) were categorized as improved or worsened by a change in FSS of either 0.5 or 1.0.Results MS patients had significantly higher FSS scores than normal controls (P < 0.001). No correlation was found between FSS and NP scores in either cross-sectional or longitudinal analyses. Fatigue was moderately correlated with depression, assessed using the Beck Depression Inventory Fast Screen (BDIFS) (r = 0.44, P < 0.001). Longitudinally, there was a medium correlation between change in FSS and BDIFS (r = 0.34, P = 0.001), but no significant differences on NP scores using either definition of change.Conclusion We conclude that self-reported fatigue, while correlated with self-reported depression, is not significantly related to cognitive capacity in MS. Multiple Sclerosis 2009; 15: 998-1005. http://msj.sagepub.com