Age-associated changes in regional aortic pulse wave velocity
Age-associated changes in regional aortic pulse wave velocity
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DOI：
10.1016/s0735-1097(01)01504-2
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发表时间：
2001-10-01
影响因子：
24
通讯作者：
Reichek, N
中科院分区：
文献类型：
--
作者：
Rogers, WJ;Hu, YL;Reichek, N
目的：本研究旨在利用相对比磁共振成像（PC-MIR）无创地确定正常人区域机械性能的年龄相关变化。有充分的文献证明，随着年龄的增长，主动脉脉波速度（PWV）逐渐增加。以前，PWV是在单个主动脉位置测量的，或者比较颈动脉和股动脉点之间的动脉波来确定PWV。方法对24名年龄21 ~ 72岁的志愿者（男性12名）进行压平眼压测量（TONO）和面内PCMR检查。在三个主动脉段测量PCMRI PWV。作为验证，TONO测定颈动脉和股动脉之间的PWV。当三个位置的PCMRI PWV平均时，与TONO没有差异（分别为7.9 +/- 2.3和7.6 +/- 2.4 m/s）。当志愿者被分为小于55岁和大于或等于55岁的两组时，年轻的一组在每个主动脉位置显示相似的PWV。然而，与胸中段或腹部段相比，老年组在升主动脉和近降主动脉区域的PWV显著增加（分别为10.6 +/- 2.5 m/s, 9.2 +/- 2.8 m/s和7.1 +/- 1.7 m/s, p < 0.001，方差分析）。结论：平面内PCMRI可以在一次采集中确定多个主动脉位置的PWV。弹性纤维的逐渐断裂和血管张力调节的改变可能导致主要影响近端主动脉的PWV与年龄相关的区域性增加。(C) 2001年由美国心脏病学会发布。
OBJECTIVES This study was designed to determine noninvasively the age-associated changes in regional mechanical properties in normals using phase-contrast magnetic resonance imaging (PC-MIR).BACKGROUND It has been well documented that there is a progressive increase in aortic pulse wave velocity (PWV) with age. Previously, PWV has been measured at a single aortic location, or has compared arterial waves between carotid and femoral points to determine PWV.METHODS Applanation tonometry (TONO) and in-plane PCMR was performed in 24 volunteers (12 men) ranging in age from 21 to 72 years old. The PCMRI PWV was measured in three aortic segments. As validation, TONO was performed to determine PWV between the carotid and femoral artery.RESULTS When PCMRI PWV was averaged over the three locations, it was not different from TONO (7.9 +/- 2.3 vs. 7.6 +/- 2.4 m/s, respectively). When the volunteers were divided into groups of < 55 and greater than or equal to 55 years old, the younger group showed similar PWV at each aortic location. However, the older group displayed significantly increased PWV in the region spanning the ascending and proximal descending aorta compared with the mid-thoracic or abdominal segments (10.6 +/- 2.5 m/s, 9.2 +/- 2.8 m/s, and 7.1 +/- 1.7 m/s, respectively, p < 0.001, analysis of variance).CONCLUSIONS In-plane PCMRI permits determination of PWV in multiple aortic locations in a single acquisition. Progressive fragmentation of elastic fibers and alterations in the regulation of vascular tone may result in an age-related, regional increase in PWV primarily affecting the proximal aorta. (C) 2001 by the American College of Cardiology.