Ruthenium(II)-Arene Metallacycles: Crystal Structures, Interaction with DNA, and Cytotoxicity
Ruthenium(II)-Arene Metallacycles: Crystal Structures, Interaction with DNA, and Cytotoxicity
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钌 (II)-芳烃金属环：晶体结构、与 DNA 的相互作用以及细胞毒性
DOI：
10.1002/ejic.201601226
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发表时间：
2017
影响因子：
2.3
通讯作者：
Liu Hong-Ke
中科院分区：
文献类型：
--
作者：
Wang Hong-Yan;Qian Yong;Wang Fang-Xin;Habtemariam Abraha;Mao Zong-Wan;Sadler Peter J.;Liu Hong-Ke
A series of 24, 26‐membered RuII2metallamacrocycles containing 1‐{3‐[(1H‐imidazol‐1‐yl)methyl]benzyl}‐1H‐imidazole (m‐bib) and 1‐{4‐[(1H‐imidazol‐1‐yl)methyl]benzyl}‐1H‐imidazole (p‐bib) ligands have been synthesized and characterized. X‐ray crystal structures of [Ru2(η6‐p‐cymene)2(m‐bib)2Cl2](CF3SO3)2(2), [Ru2(η6‐p‐cymene)2(m‐bib)2Cl2](SbF6)2(3), [Ru2(η6‐p‐cymene)2(m‐bib)2I2]I2(6), and [Ru2(η6‐p‐cymene)2(p‐bib)2Cl2](CF3SO3)2(8) were determined and found to exhibit chair‐like conformations. In general, the complexes exhibited little or moderate anti‐proliferative activity towards cancer cells [human lung cancer cells (A549), breast adenocarcinoma cells (MCF‐7), cervical epithelioid carcinoma cells (HeLa)] as well as normal liver cells (L02), except [Ru2(η6‐p‐cymene)2(p‐bib)2Cl2](NO3)2(10) (IC50= 16.7 µm), which had activity comparable with the anticancer drug cisplatin (IC50= 15.8 µm). Gel electrophoresis studies suggested that the complexes can interact with DNA and induce DNA condensation.
