Low aerobic capacity in middle-aged men associated with increased mortality rates during 45 years of follow-up
Low aerobic capacity in middle-aged men associated with increased mortality rates during 45 years of follow-up
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DOI：
10.1177/2047487316655466
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发表时间：
2016-09-01
影响因子：
8.3
通讯作者：
Hansson, Per-Olof
中科院分区：
文献类型：
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作者：
Ladenvall, Per;Persson, Carina U.;Hansson, Per-Olof
在短期研究中，低有氧能力与死亡率增加有关。本研究的目的是评估有氧代谢能力对中年男性死亡率的预测能力，随访45年。设计本研究设计是一项基于人群的前瞻性队列研究。方法从哥德堡1913年出生的男性中抽取代表性样本，随访50-99岁，定期体检和国家医院出院和死亡原因登记处的数据。在54岁时，792名男性进行了测力计运动试验，656（83%）进行最大运动test.Results在考克斯回归分析，低预测峰值摄氧量（VO 2 max），吸烟，高血清胆固醇和高平均动脉血压在休息时与死亡率显着相关。在多变量分析中，发现预测的VO 2 max三分位数与死亡率之间存在相关性，与已确定的风险因素无关。风险比为0.79（95%置信区间（CI）0.71-0.89; p
Background Low aerobic capacity has been associated with increased mortality in short-term studies. The aim of this study was to evaluate the predictive power of aerobic capacity for mortality in middle-aged men during 45-years of follow-up.Design The study design was a population-based prospective cohort study.Methods A representative sample from Gothenburg of men born in 1913 was followed from 50-99 years of age, with periodic medical examinations and data from the National Hospital Discharge and Cause of Death registers. At 54 years of age, 792 men performed an ergometer exercise test, with 656 (83%) performing the maximum exercise test.Results In Cox regression analysis, low predicted peak oxygen uptake (VO2max), smoking, high serum cholesterol and high mean arterial blood pressure at rest were significantly associated with mortality. In multivariable analysis, an association was found between predicted VO2max tertiles and mortality, independent of established risk factors. Hazard ratios were 0.79 (95% confidence interval (CI) 0.71-0.89; p