[The action of proglumide blocking gastrin on gastric cancer cells].

[The action of proglumide blocking gastrin on gastric cancer cells].
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DOI：
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发表时间：
1999-06
期刊：
Zhonghua wai ke za zhi [Chinese journal of surgery]
影响因子：
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通讯作者：
H. Wang;Q. Ni;Y. Zhang;Z. Yue;Q. Zhang;L. Hou
H. Wang;Q. Ni;Y. Zhang;Z. Yue;Q. Zhang;L. Hou
中科院分区：
其他
文献类型：
--
作者：
H. Wang;Q. Ni;Y. Zhang;Z. Yue;Q. Zhang;L. Hou

文献摘要

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OBJECTIVE To investigate the practicability of proglumide to treat gastric cancer. METHODS MKN45 gastric cancer cell line was cultured and the effects on gastrin and gastrin receptor antagonist proglumide proliferative rate, cell dynamic cycle distribution and the concentration of cAMP in the cells were observed in vitro. RESULTS Gastrin promoted the proliferation of MKN45 cells and shifted cells from phase G(0)/G(1) to phase S, G(2)/M as well as increased intracellular cAMP, while proglumide blocked these effects. CONCLUSIONS Gastrin induces the proliferation and synthesis of DNA by its receptor. Proglumide may provide a new approach of non-cytotoxic treatment of gastric cancer.