Differences in health-related quality of life by implant strategy: Analyses from the Interagency Registry for Mechanically Assisted Circulatory Support
Differences in health-related quality of life by implant strategy: Analyses from the Interagency Registry for Mechanically Assisted Circulatory Support
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DOI：
10.1016/j.healun.2019.10.002
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发表时间：
2020-01-01
影响因子：
8.9
通讯作者：
Grady, Kathleen L.
中科院分区：
文献类型：
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作者：
White-Williams, Connie;Fazeli, Pariya L.;Grady, Kathleen L.
背景：左心室辅助装置(LVAD)植入策略对健康相关生活质量(HRQOL)的中期变化尚不清楚。本研究的目的是从术前到术后2年通过植入策略来评估HRQOL。方法：根据植入前装置策略，将机构间机械辅助循环支持登记的成年患者分为3组：目的治疗(DT)(n=2,901)、搭桥移植(BTT)(n=2,209)和搭桥候选(BTC)(n=3,076)。采用一般EQ-5D-3L问卷和堪萨斯城心力衰竭特有的心肌病问卷(KCCQ-12)收集手术前和术后2年的HRQOL数据。统计分析包括卡方检验、方差分析、配对t检验和一般线性随机效应模型。结果：在2008年4月1日至2013年6月30日期间，4422例和1660例(男性占多数，年龄=50岁)的患者分别完成了基线EQ-5D-3L和KCCQ-12问卷，而1615例和1408例患者在2年时分别完成了EQ-5D-3L和KCCQ-12问卷。虽然配对t检验和一般线性随机效应模型显示，心力衰竭特有的和一般的HRQOL都随着时间的推移而在所有组中得到改善(p值
BACKGROUND: Midterm change in health-related quality of life (HRQOL) by left ventricular assist device (LVAD) implant strategy is unknown. The purpose of this study was to examine HRQOL by pre-operative implant strategy from before to 2 years after surgery.METHODS: Adult patients in the Interagency Registry for Mechanically Assisted Circulatory Support were stratified into 3 groups based on pre-implant device strategy: destination therapy (DT) (n = 2,901), bridge to transplant (BTT) (n = 2,209), and bridge to candidacy (BTC) (n = 3,076). HRQOL data were collected before and 2 years after surgery using the generic EQ-5D-3L survey and heart failure-specific Kansas City Cardiomyopathy Questionnaire (KCCQ-12). Statistical analyses included chi-square tests, analysis of variance, paired t-tests, and general linear random effects models.RESULTS: Between April 1, 2008 and June 30, 2013, 4,422 patients and 1,660 patients (majority males and = 50 years) who received primary continuous flow LVADs completed baseline EQ-5D-3L and KCCQ-12 questionnaires, respectively, whereas 1,615 and 1,408 patients completed EQ-5D-3L and KCCQ-12 questionnaires at 2 years, respectively. Although paired t-tests and general linear random effects models showed that both heart failure-specific and generic HRQOL improved for all groups across time (p-values