Signals from chloroplasts converge to regulate nuclear gene expression
Signals from chloroplasts converge to regulate nuclear gene expression
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DOI：
10.1126/science
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发表时间：
2007-05-04
期刊：
影响因子：
56.9
通讯作者：
Chory, Joanne
中科院分区：
文献类型：
--
作者：
Koussevitzky, Shai;Nott, Ajit;Chory, Joanne
质体向细胞核逆行信号协调细胞核基因表达和叶绿体功能，是植物光自养生活方式的重要组成部分。已经描述了三种逆行信号，但对它们的信号传导途径知之甚少。我们在这里表明，GUN1（叶绿体定位的五肽重复蛋白）和ABI4（无瓣花序2 （AP2）型转录因子）在这三种途径中都是共同的。ABI4通过靠近光调控元件的保守基序结合逆行调控基因的启动子。我们提出了一个模型，其中拟南芥质体功能异常的多个指标在质体GUN1上游整合，导致abi4介导的核编码基因的抑制。
Plastid-to-nucleus retrograde signaling coordinates nuclear gene expression with chloroplast function and is essential for the photoautotrophic life-style of plants. Three retrograde signals have been described, but little is known of their signaling pathways. We show here that GUN1, a chloroplast-localized pentatricopeptide-repeat protein, and ABI4, an Apetala 2 (AP2)-type transcription factor, are common to all three pathways. ABI4 binds the promoter of a retrograde-regulated gene through a conserved motif found in close proximity to a light-regulatory element. We propose a model in which multiple indicators of aberrant plastid function in Arabidopsis are integrated upstream of GUN1 within plastids, which leads to ABI4-mediated repression of nuclear-encoded genes.