Stigmastane derivatives from the roots of Vernonia guineensis and their antimicrobial activity
Stigmastane derivatives from the roots of Vernonia guineensis and their antimicrobial activity
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DOI：
10.1016/j.phytol.2012.06.002
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发表时间：
2012-09-01
影响因子：
1.7
通讯作者：
Oshima, Yoshiteru
中科院分区：
文献类型：
--
作者：
Donfack, Arno R. N.;Toyang, Ngeh J.;Oshima, Yoshiteru
Chemical investigation of the roots of Vernonia guineensis (Asteraceae) afforded a new stigmastane derivative, vernoguinoside A (1) and the known vernoguinoside (2), stigmasterol 3-O-beta-D-glucoside (3) and sitosterol 3-O-beta-D-glucoside (4). Their structures were elucidated by spectroscopic analysis. Antimicrobial activities of 1-3 and CH2Cl2-MeOH (1:1) extract were evaluated against three bacteria species (Salmonella typhi, Staphylococcus aureus and Shigella flexneri) and three yeasts species (Candida albicans, Candida parapsilosis and Cryptococcus neoformans). Compounds 1 and 2 exhibited both antibacterial and antifungal activities that varied between the microbial species (MIC = 7.81-125 mu g/mL) while S. flexneri and C. albicans were sensitive to all the tested compounds. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
