CONGENITAL HEART-DISEASE IN A COHORT OF 19,502 BIRTHS WITH LONG-TERM FOLLOW-UP
CONGENITAL HEART-DISEASE IN A COHORT OF 19,502 BIRTHS WITH LONG-TERM FOLLOW-UP
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DOI：
10.1016/0002-9149(78)90635-5
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发表时间：
1978-01-01
影响因子：
2.8
通讯作者：
CHRISTIANSON, R
中科院分区：
文献类型：
--
作者：
HOFFMAN, JIE;CHRISTIANSON, R
摘要儿童健康与发育研究是对妊娠期及后代正常和异常发育的纵向研究。参加Kaiser Foundation Health Plan的女性在妊娠早期进入研究，他们的孩子经常接受检查，直到研究中最小的孩子5岁。这是一项比迄今所报告的更为密集的后续行动。在19 044名活产婴儿中，163名患有明确先天性心脏病，另有31名可能患有先天性心脏病;每1 000名活产婴儿中，明确先天性心脏病的粗发病率为8.8，明确加上可能先天性心脏病的粗发病率为10.4。在所有接受尸检的死胎中，先天性心脏病的发病率为7.9%，而在这组尸检被评估为足够详细以检测心脏病的死胎中，先天性心脏病的发病率为10.2%。在患有先天性心脏病的活产婴儿中，21人死于新生儿期，22人死于婴儿后期和儿童期;约一半的死亡被判定为心脏病所致。大约30%的先天性心脏病患儿伴有其他系统的严重异常。在整个队列中，50名儿童被诊断出染色体异常（2.63 1,000活产），其中约30%患有先天性心脏病。在163名明确患有先天性心脏病的儿童中，46%在1周龄时确诊，88.3%在1岁时确诊，98.8%在4岁时确诊。
Abstract The Child Health and Development Studies are longitudinal studies of pregnancy and the normal and abnormal development of the offspring. Women who were members of the Kaiser Foundation Health Plan entered the study in early pregnancy, and their children were examined frequently until the youngest child in the study was 5 years old. This is a more intensive follow-up than hitherto reported. Of the 19,044 live-born children, 163 had definite and another 31 had possible congenital heart disease; the crude incidence rates per 1,000 live births were 8.8 for definite congenital heart disease and 10.4 for definite plus possible congenital heart disease. The incidence rate of congenital heart disease was 7.9 percent among all stillborn fetuses subjected to autopsy and 10.2 percent among those in this group with autopsies evaluated as being detailed enough to detect heart disease. Among the live-born children with congenital heart disease, 21 died in the neonatal period and 22 died in later infancy and childhood; about half the deaths were judged to have been due to heart disease. About 30 percent of the children with congenital heart disease had associated severe anomalies of other systems. In the whole cohort, 50 children had diagnosed chromosomal abnormalities (2.63 1,000 live births) and about 30 percent of them had congenital heart disease. Among the group of 163 children with definite congenital heart disease, the diagnosis was made in 46 percent by age 1 week, in 88.3 percent by age 1 year and in 98.8 percent by age 4 years.