Control of sperm motility and fertility: Diverse factors and common mechanisms
Control of sperm motility and fertility: Diverse factors and common mechanisms
复制标题
DOI：
10.1007/s00018-008-8230-z
复制
发表时间：
2008-07
影响因子：
8
通讯作者：
Manabu Yoshida;N. Kawano;Kaoru Yoshida
中科院分区：
文献类型：
--
作者：
Manabu Yoshida;N. Kawano;Kaoru Yoshida
睾丸中产生的精子是不成熟的，不能受精。在它们向卵子的旅程中，精子获得生育能力并实现受精。这些确保受精的精子修饰是由许多女性或男性精子外因子诱导的：例如，来自卵冻的精子运动激活因子，来自卵的精子引诱剂和来自精浆的去激活因子。控制精子生育力的因素是无数的，并且是物种特异性的;它们可能是肽、糖链或小的有机化合物。然而，受精的基本机制在所有动物中必须是共同的;[Ca 2 +]的增加触发了受精过程中的所有步骤，cAMP在许多步骤中起着重要作用。阐明精子细胞功能和形态的动态变化对于理解受精的调控具有重要意义。在这里，我们介绍了精子生育力控制的多样性和普遍性。
Spermatozoa generated in the testis are immature and incompetent for fertilization. During their journey toward the egg, the sperm acquire fertility and achieving fertilization. These sperm modifications to ensure fertilization are induced by many female or male extra-sperm factors: for example, sperm motility-activating factors from the egg jelly, sperm attractants from the eggs, and decapacitation factors from the seminal plasma. The factors controlling sperm fertility are myriad and species specific; they may be peptides, sugar chains, or small organic compounds. Nevertheless, the fundamental mechanisms underlying fertilization must be common among all animals; increase in [Ca2+]itriggers all the steps in the process of fertilization, and cAMP plays important roles in many steps. Elucidating the dynamic functional and morphological changes in sperm cells is important for understanding the regulation of fertilization. Here, we introduce the diversity and generality of the control of sperm fertility.