Mixed lateralization of phonological assembly in developmental dyslexia
Mixed lateralization of phonological assembly in developmental dyslexia
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DOI：
10.1093/neucas/8.3.205
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发表时间：
2002-01-01
期刊：
影响因子：
0.8
通讯作者：
Corballis, MC
中科院分区：
文献类型：
--
作者：
Milne, RD;Syngeniotis, A;Corballis, MC
发展性语音阅读障碍的特征是语音组合的缺陷。在神经层面上，这种缺陷可能是由左半球前后语言系统之间的弱连接所代表的。本研究使用3-特斯拉功能磁共振成像研究发展性语音阅读障碍患者的语音组合。语音阅读障碍患者的左半球额下回（ba44 /6）、右半球顶叶皮层（ba7）、枕叶皮层（ba18）和小脑的激活随着语音需求的系统性增加而增加。越来越多的证据表明，语音阅读障碍的核心功能障碍位于左半球角回及其周围。本研究支持右半球后部区域和左侧额下回的代偿作用。
Developmental phonological dyslexia has been characterized as a deficit in phonological assembly. At a neural level, it is possible that this deficit is represented by weak connectivity between anterior and posterior language systems in the left hemisphere. This study used 3-Tesla functional magnetic resonance imaging to investigate phonological assembly in a developmental phonological dyslexic. The phonological dyslexic showed increased activation in the left hemisphere of the inferior frontal gyrus (BA 44/6) and increased activation in the right hemisphere of the parietal cortex (BA 7), occipital cortex (BA 18), and in the cerebellum, as phonological demands were systematically increased. Converging evidence suggests that the core dysfunction in phonological dyslexia resides in and around the angular gyrus of the left hemisphere. This study supports the compensatory role of posterior regions in the right hemisphere together with the left inferior frontal gyrus.