Clusters of sudden unexplained death associated with the mushroom, Trogia venenata, in rural Yunnan Province, China.
Clusters of sudden unexplained death associated with the mushroom, Trogia venenata, in rural Yunnan Province, China.
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DOI：
10.1371/journal.pone.0035894
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Zeng G
中科院分区：
文献类型：
--
作者：
Shi GQ;Huang WL;Zhang J;Zhao H;Shen T;Fontaine RE;Yang L;Zhao S;Lu BL;Wang YB;Ma L;Li ZX;Gao Y;Yang ZL;Zeng G
自20世纪70年代末以来，云南省西北部地区发生的时间-空间聚集性不明原因猝死（SUD）引起了公众和卫生当局的警觉。从2006年到2009年，我们加强了对SUD的监测，以确定原因，并警告村民避免食用不熟悉的蘑菇。我们建立了SUD的监测，定义如下：突然发生严重的，原因不明的身体损害，随后在<24小时内死亡。轻度病例是SUD受害者的家庭成员或密切的社会关系群体在SUD发生后1周内发生任何疾病。我们采访了SUD的目击者和轻度病例，以确定暴露于潜在的有毒物质。我们检测了轻微病例、村民的血液，以及疾病的标准生化、酶和电解质标志物。我们确定了33个SUD，从2002-2005年下降了73%，分布在11个县的21个村庄。我们发现一种以前未描述的蘑菇，Trogia venenata，被5的7个家庭与SUD集群相比，来自同一村庄的其他31个对照家庭中的0个家庭食用。于T. SUD的特征是在正常活动期间突然失去意识。从1975年到2009年，在61个有时空SUD集群的村庄中，这种蘑菇生长在75%附近，而在18个只有单一SUD的村庄中，这种蘑菇生长在17%附近（p<0.001，Fisher精确检验）。流行病学数据表明T. venenata是云南省西北部SUD集群的可能原因。向村民们宣传食用这种蘑菇应该继续下去。
Since the late 1970's, time-space clusters of sudden unexplained death (SUD) in northwest Yunnan, China have alarmed the public and health authorities. From 2006–2009, we initiated enhanced surveillance for SUD to identify a cause, and we warned villagers to avoid eating unfamiliar mushrooms. We established surveillance for SUD, defined as follows: sudden onset of serious, unexplained physical impairment followed by death in <24 hours. A mild case was onset of any illness in a member of the family or close socially related group of a SUD victim within 1 week of a SUD. We interviewed witnesses of SUD and mild case-persons to identify exposures to potentially toxic substances. We tested blood from mild cases, villagers, and for standard biochemical, enzyme, and electrolyte markers of disease. We identified 33 SUD, a 73% decline from 2002–2005, distributed among 21 villages of 11 counties. We found a previously undescribed mushroom, Trogia venenata, was eaten by 5 of 7 families with SUD clusters compared to 0 of 31 other control-families from the same villages. In T. venenata–exposed persons SUD was characterized by sudden loss of consciousness during normal activities. This mushroom grew nearby 75% of 61 villages that had time-space SUD clusters from 1975 to 2009 compared to 17% of 18 villages with only single SUD (p<0.001, Fisher's exact test). Epidemiologic data has implicated T. venenata as a probable cause of clusters of SUD in northwestern Yunnan Province. Warnings to villagers about eating this mushroom should continue.
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影响因子：
13.2
作者：
Lee, PT;Wu, ML;Chung, HM
通讯作者：
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