ATP dependent chromatin remodeling enzymes in embryonic stem cells.
ATP dependent chromatin remodeling enzymes in embryonic stem cells.
复制标题
胚胎干细胞中 ATP 依赖性染色质重塑酶。
DOI：
10.1007/s12015-010-9120-y
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发表时间：
2010
影响因子：
4.8
通讯作者：
delaSerna,IvanaL
中科院分区：
文献类型：
--
作者：
Saladi,SrinivasVinod;delaSerna,IvanaL
胚胎干细胞是一种多能细胞，可以自我更新或被诱导分化为多个细胞系，因此具有在再生医学中应用的潜力。关键的多能性特异性因子(Oct4/Sox2/Nanog/Klf4)通过激活多能性特异性基因的表达和抑制发育调节因子的表达来维持多能性状态。多能ES细胞与分化细胞的区别在于一种特殊的染色质状态，这是在表观遗传学上调节ES细胞表型所必需的。最近的研究表明，除了多能特异性因子外，染色质重塑酶在调节ES细胞染色质以及自我更新和分化能力方面发挥着重要作用。在这里，我们综述了最近的研究，描述了ATP依赖的染色质重塑酶在调节ES细胞染色质结构中的作用。
Embryonic stem (ES) cells are pluripotent cells that can self renew or be induced to differentiate into multiple cell lineages, and thus have the potential to be utilized in regenerative medicine. Key pluripotency specific factors (Oct 4/Sox2/Nanog/Klf4) maintain the pluripotent state by activating expression of pluripotency specific genes and by inhibiting the expression of developmental regulators. Pluripotent ES cells are distinguished from differentiated cells by a specialized chromatin state that is required to epigenetically regulate the ES cell phenotype. Recent studies show that in addition to pluripotency specific factors, chromatin remodeling enzymes play an important role in regulating ES cell chromatin and the capacity to self-renew and to differentiate. Here we review recent studies that delineate the role of ATP dependent chromatin remodeling enzymes in regulating ES cell chromatin structure.