The effects of endomorphin-1 on conditioned defeat in Syrian hamsters (Mesocricetus auratus).
The effects of endomorphin-1 on conditioned defeat in Syrian hamsters (Mesocricetus auratus).
复制标题
内啡肽-1 对叙利亚仓鼠 (Mesocricetus auratus) 条件性失败的影响。
DOI：
10.1016/s0006-8993(01)02775-5
复制
发表时间：
2001
期刊：
影响因子：
2.9
通讯作者：
Huhman,KL
中科院分区：
文献类型：
--
作者：
Whitten,RD;Jasnow,AM;Albers,HE;Martin-Schild,S;Zadina,JE;Huhman,KL
本研究探讨了内吗啡肽-1（EM 1），一种对μ阿片受体具有高亲和力的内源性阿片样物质，对条件性失败的影响。条件性失败是一种现象，其中被击败的仓鼠随后未能表现出正常的领土攻击，而是表现出顺从/防御行为，即使与非攻击性入侵者配对。在实验1中，动物被放置在一个较大的居民的家笼15分钟，并被击败。24 h后，在将较小的非攻击性入侵者置于实验动物的饲养笼中之前5 min，向动物左侧脑室注射3 μl EM 1（0.0、0.3、3.0或10 nmol）。在实验2中，动物在最初失败后立即输注EM 1，并在24小时后与实验1中的非攻击性入侵者配对。EM 1能显著缩短实验1的顺从/防御行为持续时间（P<0.05），但对实验2无显著影响（P>0.05）。这些数据支持这一假设，即高选择性μ受体激动剂内吗啡肽-1调节条件性失败的表达，但没有提供支持的假设，内吗啡肽-1调节条件性失败的巩固。
The present study examined the effect of endomorphin-1 (EM1), an endogenous opioid with a high affinity for the mu opiate receptor, on conditioned defeat. Conditioned defeat is a phenomenon in which hamsters that have been defeated subsequently fail to exhibit normal territorial aggression and instead display submissive/defensive behaviors even when paired with a non-aggressive intruder. In experiment 1, animals were placed in the home cage of a larger resident for 15 min and were defeated. After 24 h, animals received a 3-μl injection of EM1 (0.0, 0.3, 3.0, or 10 nmol) into the left lateral cerebral ventricle 5 min before a smaller non-aggressive intruder was placed in the home cage of the experimental animal. In experiment 2, animals were infused with EM1 immediately after the initial defeat and were paired with a non-aggressive intruder 24 h later as in experiment 1. EM1 reduced the duration of submissive/defensive behavior in experiment 1 (P<0.05) but not in experiment 2 (P>0.05). These data support the hypothesis that the highly selective mu receptor agonist endomorphin-1 modulates the expression of conditioned defeat, but provides no support for the hypothesis that endomorphin-1 modulates the consolidation of conditioned defeat.