Renal function in pediatric patients with beta-thalassemia major.
Renal function in pediatric patients with beta-thalassemia major.
复制标题
重型β地中海贫血儿童患者的肾功能。
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
N. Dikmen
中科院分区：
文献类型：
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作者：
B. Aldudak;A. Karabay Bayazıt;A. Noyan;A. Ozel;A. Anarat;I. Şaşmaz;Y. Kilinç;E. Gali;R. Anarat;N. Dikmen
在重型β地中海贫血患者中，死亡和发病的最重要原因是由于铁沉积引起的器官衰竭。本研究探讨了肾损伤的性质和可能的发病因素。70名重型β地中海贫血患儿和14名年龄和性别匹配的健康儿童参与了这项研究。采集血液和定时尿液样本进行血液学和生化检查。两组之间的血尿素氮（BUN）、血清肌酐、肌酐清除率、血清钠、尿渗透压、钠、钾和尿酸排泄分数的平均值无统计学差异。两组间血钾、磷、尿酸水平、尿量、尿蛋白/肌酐（UP/Cr）、尿N-乙酰-β-D-氨基葡萄糖苷酶/肌酐（UNAG/Cr）、尿丙二醛/肌酐（UMDA/Cr）及肾小管磷酸盐重吸收（TRP）值比较差异有统计学意义（P<0.05）。患者组中血清钾、磷和尿酸水平升高归因于红细胞快速更新。高UP/Cr、UNAG/Cr和UMDA/Cr比值的存在表明，在这些患者中，近端肾小管损伤可能继发于铁过载介导的氧化脂质过氧化。
In patients with beta-thalassemia major, the most important cause of mortality and morbidity is organ failure due to deposits of iron. In this study, the nature of the kidney injury and possible pathogenetic factors were investigated. Seventy children with beta-thalassemia major and 14 age and sex-matched healthy children were involved in the study. Blood and timed urine samples were obtained for hematological and biochemical tests. The mean values of blood urea nitrogen (BUN), serum creatinine, creatinine clearance, serum sodium, urine osmolality, fractional excretion of sodium, potassium, and uric acid were not statistically different between the groups. Serum levels of potassium, phosphorus, and uric acid and the urine volume, high urinary protein to creatinine (UP/Cr), urinary N-acetyl-beta-D-glucosaminidase to creatinine (UNAG/Cr), and urinary malondialdehyde to creatinine, (UMDA/Cr) and the tubular phosphate reabsorption (TRP) values were statistically different between two groups (P<0.05). Increased serum levels of potassium, phosphorus, and uric acid in the patient group were attributed to the rapid erythrocyte turnover. The presence of high UP/cr, UNAG/Cr and UMDA/Cr ratios shows that in these patients with proximal renal tubular damage may be secondary to oxidative lipid peroxidation mediated by the iron overload.