Streptococcus pyogenes infection in mouse skin leads to a time-dependent up-regulation of protein H expression.
Streptococcus pyogenes infection in mouse skin leads to a time-dependent up-regulation of protein H expression.
复制标题
小鼠皮肤中的化脓性链球菌感染导致蛋白 H 表达呈时间依赖性上调。
DOI：
10.1128/iai.71.10.6079-6082.2003
复制
发表时间：
2003
影响因子：
3.1
通讯作者：
Boyle,MichaelDP
中科院分区：
文献类型：
--
作者：
Smith,TaraC;Sledjeski,DarrenD;Boyle,MichaelDP
Streptococcus pyogenesprotein H (sph) is an immunoglobulin-binding protein present in the Mga regulon of certain M1 serotype isolates. Althoughsphis present in many strains, it is frequently not expressed. In this paper we show that protein H was highly expressed after bacteria were injected into the skin of mice and were recovered from the blood, kidney, or spleen at various times postinfection. The percentage of protein H-positive colonies increased with time, reaching 100% in the spleen and kidney within 24 to 72 h postinfection. The up-regulation ofsphexpression was also observed in amgamutant.
